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Publications

Journal Article Research Support, Non-U.S. Gov't Epublish 21 citations

PubMed: 24740295 DOI: 10.1371/journal.pone.0095563

Acute moderate exercise does not further alter the autonomic nervous system activity in patients with sickle cell anemia.

PLoS One 9(4):e95563

Authors: Mona Hedreville, Keyne Charlot, Xavier Waltz, Stéphane Sinnapah, Nathalie Lemonne, Maryse Etienne-Julan, Valérie Soter, Olivier Hue, Marie-Dominique Hardy-Dessources, Jean-Claude Barthélémy, Philippe Connes

Affiliations

  • Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; Emergency Care Department, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France.
  • Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; UMR Inserm U1134 French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
  • Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.
  • Sickle cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France.
  • UMR Inserm U1134 French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; Sickle cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France.
  • Direction of Research and Innovation, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France.
  • UMR Inserm U1134 French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
  • Laboratory EA4607 SNA-EPIS, Jean Monnet University of Saint-Etienne, PRES Lyon, Saint-Etienne, France.
  • Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; UMR Inserm U1134 French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France; Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France; Institut Universitaire de France (IUF), Paris, France.

Abstract

A decreased global autonomic nervous system (ANS) activity and increased sympathetic activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and could play a role in the pathophysiology of the disease, notably by triggering vaso-occlusive crises. Because exercise challenges the ANS activity in the general population, we sought to determine whether a short (<15 min) and progressive moderate exercise session conducted until the first ventilatory threshold had an effect on the ANS activity of a group of SCA patients and a group of healthy individuals (CONT group). Temporal and spectral analyses of the nocturnal heart rate variability were performed before and on the 3 nights following the exercise session. Standard deviation of all normal RR intervals (SDNN), total power, low frequencies (LF) and high frequencies powers (HF) were lower but LF/HF was higher in SCA patients than in the CONT group. Moderate exercise did not modify ANS activity in both groups. In addition, no adverse clinical events occurred during the entire protocol. These results imply that this kind of short and moderate exercise is not detrimental for SCA patients.

MeSH

Exercise, Cells, Autonomic Nervous System, Anemia, Sickle Cell, Anemia, Nervous System

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