Journal Article Research Support, Non-U.S. Gov't Ppublish 15 citations
PubMed: 28913838 DOI: 10.1002/mrm.26926
Simultaneous acquisition of perfusion image and dynamic MR angiography using time-encoded pseudo-continuous ASL.
Magn Reson Med 79(5):2676-2684
Authors: Yuriko Suzuki, Michael Helle, Peter Koken, Marc Van Cauteren, Matthias J P van Osch
Affiliations
- C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
- Philips Electronics Japan Ltd, Healthcare, Tokyo, Japan.
- Philips GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany.
- Philips Healthcare, Asia Pacific, Tokyo, Japan.
Abstract
PURPOSE
Both dynamic magnetic resonance angiography (4D-MRA) and perfusion imaging can be acquired by using arterial spin labeling (ASL). While 4D-MRA highlights large vessel pathology, such as stenosis or collateral blood flow patterns, perfusion imaging provides information on the microvascular status. Therefore, a complete picture of the cerebral hemodynamic condition could be obtained by combining the two techniques. Here, we propose a novel technique for simultaneous acquisition of 4D-MRA and perfusion imaging using time-encoded pseudo-continuous arterial spin labeling.
METHODS
The time-encoded pseudo-continuous arterial spin labeling module consisted of a first subbolus that was optimized for perfusion imaging by using a labeling duration of 1800 ms, whereas the other six subboli of 130 ms were used for encoding the passage of the labeled spins through the arterial system for 4D-MRA acquisition. After the entire labeling module, a multishot 3D turbo-field echo-planar-imaging readout was executed for the 4D-MRA acquisition, immediately followed by a single-shot, multislice echo-planar-imaging readout for perfusion imaging. The optimal excitation flip angle for the 3D turbo-field echo-planar-imaging readout was investigated by evaluating the image quality of the 4D-MRA and perfusion images as well as the accuracy of the estimated cerebral blood flow values.
RESULTS
When using 36 excitation radiofrequency pulses with flip angles of 5 or 7.5°, the saturation effects of the 3D turbo-field echo-planar-imaging readout on the perfusion images were relatively moderate and after correction, there were no statistically significant differences between the obtained cerebral blood flow values and those from traditional time-encoded pseudo-continuous arterial spin labeling.
CONCLUSIONS
This study demonstrated that simultaneous acquisition of 4D-MRA and perfusion images can be achieved by using time-encoded pseudo-continuous arterial spin labeling. Magn Reson Med 79:2676-2684, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
MeSH
Blood, Angiography, Blood Circulation, Perfusion Imaging
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- Time-encoded golden angle radial arterial spin labeling: Simultaneous acquisition of angiography and perfusion data. NMR Biomed, 2022
- Off-resonance correction for pseudo-continuous arterial spin labeling using the optimized encoding scheme. Neuroimage, 2020
- Recent Technical Developments in ASL: A Review of the State of the Art. Magn Reson Med, 2022
- Intracranial 3D and 4D MR Angiography Using Arterial Spin Labeling: Technical Considerations. Magn Reson Med Sci, 2021
- Ultra-high temporal resolution 4D angiography using arterial spin labeling with subspace reconstruction. Magn Reson Med, 2025