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Journal Article Epublish 19 citations

PubMed: 29506549 DOI: 10.1186/s12944-018-0689-5

Lipid profiles in French West Indies sickle cell disease cohorts, and their general population.

Lipids Health Dis 17(1):38

Authors: Marie-Laure Lalanne-Mistrih, Philippe Connes, Yann Lamarre, Nathalie Lemonne, Marie-Dominique Hardy-Dessources, Vanessa Tarer, Maryse Etienne-Julan, Dominique Mougenel, Benoît Tressières, Marc Romana

Affiliations

  • Université des Antilles, CHU de Pointe-à-Pitre, Guadeloupe, Université Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge UMR_S1134, laboratoire d'Excellence GR-Ex, Paris, France.
  • Centre d'investigation Clinique Antilles Guyane, Inserm/DGOS CIC 14-24, enceinte de l'Institut Pasteur, Pointe-À-Pitre, Guadeloupe, France.
  • Institut Universitaire de France, Paris, France.
  • Laboratoire LIBM EA7424, Equipe « Biologie Vasculaire et du Globule Rouge », Laboratoire d'Excellence GR-Ex, Université de Lyon, Lyon, France.
  • Unité Transversale de la Drépanocytose, CHU de Pointe à Pitre, Pointe-à-Pitre, Guadeloupe, France.
  • Université des Antilles, CHU de Pointe-à-Pitre, Guadeloupe, Université Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge UMR_S1134, laboratoire d'Excellence GR-Ex, Paris, France.
  • UMR Inserm 1134, Hôpital Ricou, CHU de Pointe-à-Pitre, 97 157, Pointe-à-Pitre, Guadeloupe, France.

Abstract

BACKGROUND

The pathophysiology of sickle cell disease (SCD) and the variability of its clinical expression remain not fully understood, whether within or between different SCD genotypes. Recent studies have reported associations between lipid levels and several SCD complications. If lipid levels have been previously described as low in sickle cell anemia (SCA), few data have been provided for sickle cell SC disease (SCC). We designed our epidemiological study to isolate lipid levels and profiles by genotype in Guadeloupian cohorts of SCA and SCC adult patients, at steady state. We compared SCD lipid levels with those of the Guadeloupian general population (GGP), and analyzed potential associations between lipid levels and SCD complications (vaso-occlusive crises, acute chest syndrome and osteonecrosis).

METHODS

Lipids, apolipoproteins, biological variables and anthropometric evaluation, were collected at steady state from medical files for 62 SCC and 97 SCA adult patients. Clinical SCD complications were collected from the clinical files. Analysis was conducted by genotype for all variables.

RESULTS

Different SCC and SCA lipid profiles, both distinct from their GGP's, were identified. Compared to SCC and GGP, higher triglyceride (TG) levels were observed in SCA patients, independent of hydroxyurea, hemolysis, gender, age, body mass index (BMI), abdominal obesity and clinical nutritional status. Our survey highlights also subsequent anthropometrical phenotypes, with an over-representation of abdominal obesity with normal BMI in SCA patients, and affecting almost exclusively females in both genotypes. Moreover, more frequent positive history of acute chest syndrome (ACS) was observed in SCA patients with TG level higher than 1.50 g/l, and of osteonecrosis in SCC patients having non high-density lipoprotein-cholesterol level (Non HDL-C) higher than 1.30 g/l.

CONCLUSIONS

This study reveals that SCA and SCC patients exhibit distinct lipid profiles and suggests that high TG and Non HDL-C levels are associated with past histories of ACS and osteonecrosis in SCA and SCC patients, respectively.

MeSH

Cells, Anemia, Sickle Cell, Lipoproteins, Obesity, Genotype, Acute Chest Syndrome, Obesity, Abdominal, History, Osteonecrosis

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