Journal Article Research Support, Non-U.S. Gov't Review Ppublish 279 citations
PubMed: 29532805 DOI: 10.1038/nrurol.2018.20
Sexual dysfunction and male infertility.
Nat Rev Urol 15(5):287-307
Authors: Francesco Lotti, Mario Maggi
Affiliations
- Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Abstract
Infertility affects up to 12% of all men, and sexual dysfunction occurs frequently in men of reproductive age, causing infertility in some instances. In infertile men, hypoactive sexual desire and lack of sexual satisfaction are the most prevalent types of sexual dysfunction, ranging from 8.9% to 68.7%. Erectile dysfunction and/or premature ejaculation, evaluated with validated tools, have a prevalence of one in six infertile men, and orgasmic dysfunction has a prevalence of one in ten infertile men. In addition, infertile men can experience a heavy psychological burden. Infertility and its associated psychological concerns can underlie sexual dysfunction. Furthermore, general health perturbations can lead to male infertility and/or sexual dysfunction. Erectile dysfunction and male infertility are considered proxies for general health, the former underlying cardiovascular disorders and the latter cancerous and noncancerous conditions. The concept that erectile dysfunction in infertile men might be an early marker of poor general health is emerging. Finally, medications used for general health problems can cause sperm abnormalities and sexual dysfunction. The treatment of some causes of male infertility might improve semen quality and reverse infertility-related sexual dysfunction. In infertile men, an investigation of sexual, general, and psychological health status is advisable to improve reproductive problems and general health.
MeSH
Erectile Dysfunction, Infertility, Urologic Diseases, Prevalence, Infertility, Male
Cited by
- A population-based study of the epidemiology and the risk factors for male infertility in Kuwait. Urol Ann, 2021
- The Etiology of Infertility Affects Fertility Quality of Life of Males Undergoing Fertility Workup and Treatment. Am J Mens Health, 2021
- Some of the Factors Involved in Male Infertility: A Prospective Review. Int J Gen Med, 2020
- Relationship between cadmium content in semen and male infertility: a meta-analysis. Environ Sci Pollut Res Int, 2019
- Male Infertility in Humans: An Update on Non-obstructive Azoospermia (NOA) and Obstructive Azoospermia (OA). Adv Exp Med Biol, 2021
- Metabolic, Oxidative and Psychological Stress as Mediators of the Effect of COVID-19 on Male Infertility: A Literature Review. Int J Environ Res Public Health, 2022
- Male Sexual Dysfunctions in the Infertile Couple-Recommendations From the European Society of Sexual Medicine (ESSM). Sex Med, 2021
- Psychological distress, emotion regulation, neuroticism, and sexual relationship on patients with temporary ejaculation failure fertilization-embryo transfer treatment. Front Psychol, 2023
- Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Netw Open, 2023
- Hypogonadism and sexual function in men affected by adrenocortical carcinoma under mitotane therapy. Front Endocrinol (Lausanne), 2024
- Superhydrophobic Soot Coated Quartz Crystal Microbalances: A Novel Platform for Human Spermatozoa Quality Assessment. Sensors (Basel), 2019
- Prevalence of sexual dysfunction among the male populations who seeking medical care for infertility, pregnancy loss and preconception care: a cross-sectional study. Sci Rep, 2022
- Genetics of Azoospermia. Int J Mol Sci, 2021
- Direct and Gradual Electrical Testicular Shocks Stimulate Spermatogenesis and Activate Sperms in Infertile Men: A Randomized Controlled Trial. Am J Mens Health, 2024
- The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review. Front Endocrinol (Lausanne), 2022
- Metabolic Syndrome and Reproduction. Int J Mol Sci, 2021
- Biogenesis of stress granules and their role in the regulation of stress-induced male reproduction disorders. Cell Commun Signal, 2025
- Video platforms and sexual healthcare in China: assessment of content on premature ejaculation. Transl Androl Urol, 2025
- Influence of Lisdexamfetamine Dimesylate on Early Ejaculation-Results from a Double-Blind Randomized Clinical Trial. Healthcare (Basel), 2021
- Sexual dysfunction among men with diabetes mellitus attending chronic out-patient department at the three hospitals of Northwest Amhara region, Ethiopia: Prevalence and associated factors. PLoS One, 2021