Journal Article Research Support, Non-U.S. Gov't Ppublish 18 citations
PubMed: 29790622 DOI: 10.1111/adb.12635
Effects of alcohol exposure on the glutamatergic system: a combined longitudinal F-FPEB and H-MRS study in rats.
Addict Biol 24(4):696-706
Authors: Bart de Laat, Akila Weerasekera, Gil Leurquin-Sterk, Willy Gsell, Guy Bormans, Uwe Himmelreich, Cindy Casteels, Koen Van Laere
Affiliations
- KU Leuven - University of Leuven, MoSAIC, Molecular Small Animal Imaging Center, Belgium.
- KU Leuven - University of Leuven/University Hospital Leuven, Division of Nuclear Medicine, Department of Imaging and Pathology, Belgium.
- KU Leuven - University of Leuven, Biomedical MRI unit, Department of Imaging and Pathology, Belgium.
- KU Leuven - University of Leuven, Laboratory for Radiopharmacy, Department of Pharmaceutical and Pharmacological Sciences, Belgium.
Abstract
In a longitudinal rat model of alcohol consumption, we showed that exposure to alcohol decreased the concentration of glutamate in the prefrontal cortex, whereas a normalization occurred during abstinence. 18F-FPEB PET scans revealed that pre-exposure mGluR5 availability in the nucleus accumbens was associated with future alcohol preference. Finally, alcohol exposure induced a decrease in mGluR5 availability in the bilateral hippocampus and amygdala compared with baseline, and in the hippocampus and striatum compared with saccharin (Figure).
MeSH
Tobacco Use Disorder, Alcoholism, Hippocampus, Positron-Emission Tomography, Receptor, Metabotropic Glutamate 5
Cited by
- Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience. Front Med (Lausanne), 2019
- Recovery of Decreased Metabotropic Glutamate Receptor 5 Availability in Abstinent Alcohol-Dependent Patients. J Nucl Med, 2020
- Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect. Brain Sci, 2019
- Ampicillin/Sulbactam Treatment Modulates NMDA Receptor NR2B Subunit and Attenuates Neuroinflammation and Alcohol Intake in Male High Alcohol Drinking Rats. Biomolecules, 2021
- Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations. Adv Pharmacol, 2020
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