Comparative Study Journal Article Research Support, Non-U.S. Gov't Epublish 26 citations
PubMed: 30121591 DOI: 10.1136/bmjopen-2017-020293
Risk of metabolic disorders in childless men: a population-based cohort study.
BMJ Open 8(8):e020293
Authors: Ane Berger Bungum, Clara Helene Glazer, Jens Peter Bonde, Peter M Nilsson, Aleksander Giwercman, Sandra Søgaard Tøttenborg
Affiliations
- Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Kobenhavn, Denmark. Molecular Reproductive Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden.
- Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Kobenhavn, Denmark.
- Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital, Malmö, Sweden.
- Molecular Reproductive Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden.
Abstract
OBJECTIVE
To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes.
DESIGN
A population-based cohort study.
SETTING
Not applicable.
PARTICIPANTS
2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort.
INTERVENTIONS
None.
MAIN OUTCOME MEASURES
From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men.
RESULTS
At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)).
CONCLUSION
This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.
MeSH
Diabetes Mellitus, Cross-Sectional Studies, Infertility, Cohort Studies, Prevalence, Metabolic Syndrome
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- Male Infertility and Reduced Life Expectancy: Epidemiology, Mechanisms, and Clinical Implications. J Clin Med, 2025
- Association between Parenthood and Health Behaviour in Later Life-Results from the Population-Based CARLA Study. Int J Environ Res Public Health, 2022
- Metabolic Syndrome and Reproduction. Int J Mol Sci, 2021
- Male childlessness as independent predictor of risk of cardiovascular and all-cause mortality: A population-based cohort study with more than 30 years follow-up. PLoS One, 2020
- Impact of genetic risk score on the association between male childlessness and cardiovascular disease and mortality. Sci Rep, 2021
- RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity. Andrology, 2022
- A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer. Front Oncol, 2021
- Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study. Int J Environ Res Public Health, 2022
- Hypertension and Reproduction. Curr Hypertens Rep, 2020