System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Epublish 7 citations

PubMed: 31947773 DOI: 10.3390/jcm9010133

One-Fifth of Children with Sickle Cell Anemia Show Exercise-Induced Hemoglobin Desaturation: Rate of Perceived Exertion and Role of Blood Rheology.

J Clin Med 9(1)

Authors: Valentine Brousse, Corinne Pondarre, Cecile Arnaud, Annie Kamden, Mariane de Montalembert, Benedicte Boutonnat-Faucher, Hélène Bourdeau, Keyne Charlot, David Grévent, Suzanne Verlhac, Lydie da Costa, Philippe Connes

Affiliations

  • Service de Pédiatrie Générale et Maladies infectieuses, Hôpital Necker Enfants Malades, AP-HP, 75015 Paris, France.
  • LABEX GR-Ex, F-75015 Paris, France.
  • UMR_S1134, Inserm, Institut National de la transfusion sanguine, 75015 Paris, France.
  • Service de Pédiatrie, Centre Intercommunal de Créteil, 94000 Créteil, France.
  • Service d'Hématologie Biologique, Hôpital Robert Debré, AP-HP, 75019 Paris, France.
  • Unité de Physiologie des Exercices et Activités en Conditions Extrêmes, Département Environnements Opérationnels Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France.
  • Service d'Imagerie Pédiatrique, Hôpital Necker Enfants Malades, AP-HP, F-75015 Paris, France.
  • Service de Radiologie, Centre Intercommunal de Créteil, 94000 Créteil, France.
  • Paris University, F-75010 Paris, France.
  • Equipe «Biologie Vasculaire et du Globule Rouge», Laboratoire LIBM EA7424, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France.
  • Institut Universitaire de France, 75015 Paris, France.

Abstract

Perceived exertion is an important self-limiting factor influencing functional capacity in patients with sickle cell anemia (SCA). Exercise-related hemoglobin desaturation (EHD) may occur during a six-minute walking test (6MWT) and could influence the perceived rate of exertion. The aims of this study were (1) to compare the 6MWT responses (heart rate, perceived rate of exertion, and distance covered) between SCA children with and without EHD, and (2) to test the associations between EHD and several biological/physiological parameters. Nine of 51 SCA children (18%) at steady state (mean age 11.9 ± 3.8 years) exhibited EHD at the end of the 6MWT. The rate of perceived exertion increased with exercise in the two groups, but reached higher values in the EHD group. Heart rate and performance during the 6MWT did not differ between the two groups. The magnitude of change in SpO2 during the 6MWT was independently associated with the red blood cell (RBC) deformability and RBC aggregates strength. This study demonstrates that SCA children with EHD during a 6MWT have a higher rate of perceived exertion than non-EHD children despite a similar physiological demand, and that abnormal RBC rheology determinants appear to be significant contributors.

MeSH

Physical Exertion, Anemia, Sickle Cell, Child, Cells, Exercise, Blood, Rheology, Hemoglobins

Cited by