Journal Article Epublish 7 citations
PubMed: 32320397 DOI: 10.1371/journal.pntd.0008165
Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017.
PLoS Negl Trop Dis 14(4):e0008165
Authors: Sangay Zangmo, Jit Bdr Darnal, Tsheten, Sonam Gyeltshen, Binay Thapa Thapa, Prinyada Rodpradit, Piyawan Chinnawirotpisan, Wudtichai Manasatienkij, Louis R Macareo, Stefan Fernandez, Sonam Wangchuk, Chonticha Klungthong
Affiliations
- Royal Centre for Disease Control, Ministry of Health, Thimphu, Bhutan.
- Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Abstract
Dengue continues to pose a significant public health problem in tropical and subtropical countries. In Bhutan, first outbreak of dengue fever (DF) was reported in 2004 in a southern border town, followed by sporadic cases over the years. In this study, we analysed DF outbreaks that occurred in 3 different places during the years 2016 and 2017. A total of 533 cases in 2016 and 163 in 2017 were suspected of having of DF, where young adults were mostly affected. A total of 240 acute serum specimens collected and analyzed for serotype by nested RT-PCR revealed predominance of serotypes 1 and 2 (DENV-1 and 2). Phylogenetic analysis using envelope gene for both the serotypes demonstrated cosmopolitan genotype which were closely related to strains from India, indicating that they were probably imported from the neighboring country over the past few years.
MeSH
Tropical Medicine, Dengue, Genes, Disease Outbreaks, Molecular Epidemiology
Cited by
- Epidemiological Analysis of the 2019 Dengue Epidemic in Bhutan. Int J Environ Res Public Health, 2021
- Comparative phylogenetic analysis and transcriptomic profiling of Dengue (DENV-3 genotype I) outbreak in 2021 in Bangladesh. Virol J, 2023
- Global Evolutionary History and Dynamics of Dengue Viruses Inferred from Whole Genome Sequences. Viruses, 2022