Journal Article Research Support, N.I.H., Extramural Ppublish 17 citations
PubMed: 32417884 DOI: 10.1093/infdis/jiaa257
Enhanced Human Immunodeficiency Virus-1 Replication in CD4+ T Cells Derived From Individuals With Latent Mycobacterium tuberculosis Infection.
J Infect Dis 222(9):1550-1560
Authors: Xianbao He, Jared J Eddy, Karen R Jacobson, Andrew J Henderson, Luis M Agosto
Affiliations
- Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.
- Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA.
Abstract
BACKGROUND
Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) coinfection increases mortality, accelerates progression to acquired immune deficiency syndrome, and exacerbates tuberculosis disease. However, the impact of pre-existing Mtb infection on subsequent HIV infection has not been fully explored. We hypothesized that Mtb infection creates an immunological environment that influences the course of HIV infection, and we investigated whether pre-existing Mtb infection impacts the susceptibility of CD4+ T cells to HIV-1 infection.
METHODS
Plasma and blood CD4+ T cells isolated from HIV-negative individuals across the Mtb infection spectrum and non-Mtb-infected control individuals were analyzed for inflammation markers and T-cell phenotypes. CD4+ T cells were infected with HIV-1 in vitro and were monitored for viral replication.
RESULTS
We observed differences in proinflammatory cytokines and the relative proportion of memory T-cell subsets depending on Mtb infection status. CD4+ T cells derived from individuals with latent Mtb infection supported more efficient HIV-1 transcription, release, and replication. Enhanced HIV-1 replication correlated with higher percentages of CD4+ TEM and TTD cells.
CONCLUSIONS
Pre-existing Mtb infection creates an immunological environment that reflects Mtb infection status and influences the susceptibility of CD4+ T cells to HIV-1 replication. These findings provide cellular and molecular insights into how pre-existing Mtb infection influences HIV-1 pathogenesis.
MeSH
Cells, Hiv-1, Mycobacterium, Hiv, Tuberculosis, Viruses, Hiv Infections, Environment, Communicable Diseases, Mycobacterium Tuberculosis, Infections
Cited by
- Systems biology approaches to investigate the role of granulomas in TB-HIV coinfection. Front Immunol, 2022
- Different diets and their effect on tuberculosis prevention in HIV patients. J Family Med Prim Care, 2022
- Mycobacterium tuberculosis infection, immune activation, and risk of HIV acquisition. PLoS One, 2022
- Pathogenesis of Human Immunodeficiency Virus- Co-Infection. J Clin Med, 2020
- Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in Brazil. Front Med (Lausanne), 2022