Abstract

OBJECTIVE

To determine the outcome of the vaccination against hepatitis, we determined the prevalence of hepatitis B virus (HBV) and hepatitis D virus (HDV) infections, eight years after introduction of the vaccination.

MATERIALS AND METHODS

A cross-sectional study was performed in 2 944 participants of 67 Kandozi and Chapra indigenous peoples in April 2010. Serological screening for hepatitis B surface antigen (HBsAg), antibody anti-HBc IgM and IgG, antibody anti-HBs and anti-HDV were determined by ELISA tests.

RESULTS

The prevalence rates of HBsAg, anti-HBc total, anti- HBs ≥10 mlUI/ml and anti-HDV were 2.3, 39.13, 50.95 and 2.11%, respectively. The prevalence rate of HBsAg in children <11 years was 0%. Among carriers of HBsAg, the prevalence rates of HDV and acute HBV infections were 2.11% (all were >14 years) and 11.94%, respectively. HBsAg and anti-HBc total were associated with individuals ≥10 years (p<0.001).

CONCLUSIONS

These findings show the elimination of HBVmcarriers in children <11 years, eight years following introduction of the vaccination against HBV.

MeSH

Hepatitis B Surface Antigens, Immunization, Vaccines, Public Health, Vaccination, Viruses, Prevalence, Hepatitis B, Infections, Hepatitis, Child

Cited by

• A Survey of Hepatitis B Virus and Hepatitis E Virus at the Human-Wildlife Interface in the Peruvian Amazon. Microorganisms, 2024
• [Hepatitis B in indigenous people in Latin America: a literature reviewHepatite B em indígenas na América Latina: revisão da literatura]. Rev Panam Salud Publica, 2022
• Forty-Five Years after the Discovery of the Hepatitis D Virus: Where Do We Stand? Viruses, 2021