Journal Article Review Ppublish 19 citations
PubMed: 32648379 DOI: 10.5534/wjmh.200084
The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review.
World J Mens Health 39(3):391-398
Authors: Rafael F Ambar, Ashok Agarwal, Ahmad Majzoub, Sarah Vij, Nicholas N Tadros, Chak Lam Cho, Neel Parekh, Edson Borges, Sidney Glina
Affiliations
- American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
- Department of Urology, Centro Universitario em Saude do ABC/Andrology Group at Ideia Fertil Institute of Human Reproduction, Santo André, Brazil.
- Hope Clinic-Human Reproduction, São Paulo, Brazil.
- American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
- Department of Urology, Hamad Medical Corporation, Qatar.
- Weill Cornell Medicine-Qatar, Doha, Qatar.
- Department of Urology, Cleveland Clinic, Cleveland, OH, USA.
- Division of Urology, Southern Illinois University, Springfield, IL, USA.
- Department of Surgery, Union Hospital, Hong Kong. S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong.
- Fertility Medical Group, Sapientiae Institute, São Paulo, Brazil.
- Department of Urology, Centro Universitario em Saude do ABC, Santo André, Brazil.
Abstract
The advent of intracytoplasmic sperm injection (ICSI) has changed the human reproduction landscape by overcoming several limitations related to both male and female infertility factors. However, despite the development of new technologies, the live-birth rate with ICSI has not exceeded 30%. In order to improve assisted reproductive technology outcomes, advanced sperm function analysis have gained increased attention and the effects of sperm DNA fragmentation (SDF) on assisted reproduction success are being extensively studied. Utilizing ejaculated sperm with an elevated SDF has been found to result in poor ICSI outcomes. Furthermore, studies have reported that testicular sperm has lower SDF level, when compared to ejaculated sperm. This has led a number of clinicians world-wide to offer testicular sperm retrieval for ICSI in non-azoospermic males with high SDF. This practice has remained controversial due to lack of high quality evidence.
MeSH
Injections, Reproduction, Sperm Injections, Intracytoplasmic, Spermatozoa, Dna, Dna Damage
Cited by
- From Diagnosis to Treatment: Comprehensive Care by Reproductive Urologists in Assisted Reproductive Technology. Medicina (Kaunas), 2023
- Sperm DNA fragmentation testing in clinical management of reproductive medicine. Reprod Med Biol, 2023
- Testicular sperm extraction for men with cryptozoospermia - are we jumping the gun? Arab J Urol, 2024
- The Sperm Small RNA Transcriptome: Implications beyond Reproductive Disorder. Int J Mol Sci, 2022
- Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines. World J Mens Health, 2021
- Recent advances and controversies in diagnosing and treating male infertility. Fac Rev, 2021
- Outcomes comparison of testicular versus ejaculated sperm for intracytoplasmic sperm injection in infertile men with high DNA fragmentation: updated systematic review and meta-analysis. Transl Androl Urol, 2024
- Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations. World J Mens Health, 2023
- Multi-Omics Perspectives on Testicular Aging: Unraveling Germline Dysregulation, Niche Dysfunction, and Epigenetic Remodeling. Cells, 2025
- Tissue and sperm handling before assisted reproductive technology (ART): A systematic review. Arab J Urol, 2021