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Publications

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Ppublish 13 citations

PubMed: 32713707 DOI: 10.1016/j.jdiacomp.2020.107676

Cardiovascular risk and heart rate variability in young adults with type 2 diabetes and arterial stiffness: The SEARCH for Diabetes in Youth Study.

J Diabetes Complications 34(10):107676

Authors: Amy Sanghavi Shah, Mamta Jaiswal, Dana Dabelea, Jasmin Divers, Scott Isom, Angela D Liese, Jean M Lawrence, Grace Kim, Elaine M Urbina

Affiliations

  • Cincinnati Children's Hospital Medical Center and the University of Cincinnati, United States of America.
  • Department of Neurology, University of Michigan, Ann Arbor, MI, United States of America.
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, United States of America.
  • Division of Health Services Research, NYU Long Island School of Medicine, Mineola, NY, United States of America.
  • Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
  • Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States of America.
  • Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States of America.
  • Seattle Children's Hospital, Seattle, WA, United States of America.
  • Cincinnati Children's Hospital Medical Center and the University of Cincinnati, United States of America.

Abstract

AIMS

To evaluate cardiovascular risk factors and heart rate variability (HRV) in young adults with type 2 diabetes and arterial stiffness and to explore the relationship between HRV and arterial stiffness.

METHODS

We studied 185 young adults with youth-onset T2D enrolled in the SEARCH for Diabetes in Youth Study. Cardiovascular risk factors and HRV were compared between individuals with and without type 2 diabetes and arterial stiffness (defined as a pulse wave velocity greater than the 90th percentile of healthy controls, >6.767 m/s). Semiparametric regression evaluated the independent relationship between HRV and PWV.

RESULTS

Participants with T2D and arterial stiffness were more likely to be older, non-Hispanic Black, have higher systolic and diastolic blood pressure, greater adiposity and obesity-related dyslipidemia (higher triglycerides and lower HDLC). Participants with T2D and arterial stiffness also had lower overall HRV (lower SDNN) with parasympathetic loss (lower RMSSD and PNN50), p < 0.05. Lower HRV tended to be but was not significantly associated with arterial stiffness after adjustment for age, race/ethnicity, sex and cardiovascular risk factors (beta coefficient = -1.11, p = 0.08).

CONCLUSIONS

Youth with T2D and arterial stiffness have a worse cardiovascular risk profile, specifically risk factors related to the metabolic syndrome and lower HRV.

MeSH

Risk Factors, Heart Rate, Diabetes Complications, Diabetes Mellitus, Type 2

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