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Publications

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Ppublish 6 citations

PubMed: 34120091 DOI: 10.1016/j.neurobiolaging.2021.05.004

Red cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adults.

Neurobiol Aging 105:229-240

Authors: May A Beydoun, Danielle Shaked, Sharmin Hossain, Jordan Weiss, Hind A Beydoun, Ana I Maldonado, Leslie I Katzel, Christos Davatzikos, Rao P Gullapalli, Stephen L Seliger, Guray Erus, Michele K Evans, Alan B Zonderman, Shari R Waldstein

Affiliations

  • Laboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA.
  • Department of Psychology, VA Boston Healthcare System, Boston, MA, USA.
  • Laboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA.
  • Department of Demography, University of California, Berkeley, Berkeley, CA, USA.
  • Department of Research Programs, Fort Belvoir Community Hospital, Fort Belvoir, VA, USA.
  • Laboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA; Department of Psychology, University of Maryland Baltimore County, Catonsville, MD, USA.
  • Geriatric Research Education and Clinical Center, Baltimore VA Medical Center, Baltimore, MD, USA; Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Artificial Intelligence in Biomedical Imaging Lab, Center for Biomedical Image Computing and Analytics (CBICA), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
  • Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Department of Psychology, University of Maryland Baltimore County, Catonsville, MD, USA; Geriatric Research Education and Clinical Center, Baltimore VA Medical Center, Baltimore, MD, USA; Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Abstract

Anemia (blood hemoglobin [Hb] <13 g/dL among males; <12 g/dL among females) and elevated red cell distribution width (RDW) are potential risk factors for reduced brain white matter integrity (WMI), reflected by lower fractional anisotropy or increased mean diffusivity. Cross-sectional data with exposure-outcome lag time was used, whereby hematological exposures (RDW and Hb) and covariates were compiled from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study with available visit 1 (v 1; 2004-2009) and/or v 2 (2009-2013) data; while diffusion tensor magnetic resonance imaging (dMRI) outcome data were collected at HANDLS SCAN visit (v scan: 2011-2015, n = 214, mean follow-up from v 1 ±SD: 5.6 ± 1.8 year). Multivariable-adjusted linear regression analyses were conducted, overall, stratifying by sex, and further restricting to the nonanemic for RDW exposures in part of the analyses. Among males, RDW (v1) was linked with lower global mean fractional anisotropy (standardized effect size b = -0.30, p= 0.003, q < 0.05; basic model), an association only slightly attenuated with further covariate adjustment. Anemia was not a risk factor for poor WMI, independently of RDW. Ultimately, pending further longitudinal evidence, initial RDW appears to be associated with poorer WMI among males.

MeSH

White Matter, Cells, Anemia, Aging, Aged, Neurophysiology, Risk Factors

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