Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Twin Study Ppublish 2 citations
PubMed: 34186076 DOI: 10.1016/j.envres.2021.111604
A Co-Twin control study of fine particulate matter and the prevalence of metabolic syndrome risk factors.
Environ Res 201:111604
Authors: Yuhan Zhang, Liuhua Shi, Howard Chang, Joel Schwartz, Qian Di, Jack Goldberg, Viola Vaccarino
Affiliations
- Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.
- Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.
- Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.
- Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
- Vanke School of Public Health, Tsinghua University, Beijing, 100084, China.
- Vietnam Era Twin Registry, Seattle Epidemiologic Research and Information Center, US Department of Veterans Affairs, Seattle, WA, 98174, USA.
- Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.
Abstract
The relationship between ambient fine particulate matter (PM) and metabolic syndrome (MetS) is understudied. It also remains unknown whether familial factors play a role in this relationship. In a study of 566 middle-aged twins, we examined the association of PM with MetS risk factors, measured by a MetS score as a summation of individual risk factors (range, 0 to 5). High-resolution PM estimates were obtained through previously validated models that incorporated monitor and satellite derived data. We estimated two-year average PM concentrations based on the ZIP code of each twin's residence. We used ordinal response models adapted for twin studies. When treating twins as individuals, the odds ratio of having 1-point higher MetS score was 1.78 for each 10 μg/m-increase in exposure to PM (confidence interval [CI]: 1.01, 3.15), after adjusting for potential confounders. This association was mainly between pairs; the odds ratio was 1.97 (CI: 1.01, 3.84) for each 10 μg/m-increase in the average pairwise exposure level. We found no significant difference in MetS scores within pairs who were discordant for PM exposure. In conclusion, higher PM in residence area is associated with more MetS risk factors. This association, however, is confounded by shared familial factors.
MeSH
Risk Factors, Odds Ratio, Particulate Matter, Environmental Health, Metabolic Syndrome, Prevalence