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Publications

Journal Article Epublish 5 citations

PubMed: 34299006 DOI: 10.3390/ijms22147389

Disease Differentiation and Monitoring of Anti-TNF Treatment in Rheumatoid Arthritis and Spondyloarthropathies.

Int J Mol Sci 22(14)

Authors: Katarzyna Bogunia-Kubik, Wojciech Wojtowicz, Jerzy Swierkot, Karolina Anna Mielko, Badr Qasem, Joanna Wielińska, Renata Sokolik, Łukasz Pruss, Piotr Młynarz

Affiliations

  • Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
  • Department of Bioorganic Chemistry, Wroclaw University of Technology, 50-370 Wroclaw, Poland.
  • Department of Rheumatology and Internal Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland.
  • Ardigen, 30-394 Krakow, Poland.

Abstract

Rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) are comprehensive immunological disorders. The treatment of these disorders is limited to ameliorating the symptoms and improving the quality of life of patients. In this study, serum samples from RA, AS, and PsA patients were analyzed with metabolomic tools employing the 1H NMR method in combination with univariate and multivariate analyses. The results obtained in this study showed that the changes in metabolites were the highest for AS > RA > PsA. The study demonstrated that the time until remission or until low disease activity is achieved is shortest (approximately three months) for AS, longer for RA and longest for PsA. The statistically common metabolite that was found to be negatively correlated with the healing processes of these disorders is ethanol, which may indicate the involvement of the gut microflora and/or the breakdown of malondialdehyde as a cell membrane lipid peroxide product.

MeSH

Arthritis, Psoriatic, Spondylitis, Ankylosing, Arthritis, Metabolomics, Membrane Lipids, Arthritis, Rheumatoid, Therapeutics, Spondylarthropathies

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