Journal Article Review Epublish 8 citations
PubMed: 34360940 DOI: 10.3390/ijms22158174
Heme Burden and Ensuing Mechanisms That Protect the Kidney: Insights from Bench and Bedside.
Int J Mol Sci 22(15)
Authors: József Balla, Abolfazl Zarjou
Affiliations
- ELKH-UD Vascular Biology and Myocardial Pathophysiology Research Group, Division of Nephrology, Department of Medicine, Faculty of Medicine, Hungarian Academy of Sciences, H-4032 Debrecen, Hungary.
- Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, 618 Zeigler Research Building, 703 South 19th Street, Birmingham, AL 35294, USA.
Abstract
With iron at its core, the tetrapyrrole heme ring is a cardinal prosthetic group made up of many proteins that participate in a wide array of cellular functions and metabolism. Once released, due to its pro-oxidant properties, free heme in sufficient amounts can result in injurious effects to the kidney and other organs. Heme oxygenase-1 (HO-1) has evolved to promptly attend to such injurious potential by facilitating degradation of heme into equimolar amounts of carbon monoxide, iron, and biliverdin. HO-1 induction is a beneficial response to tissue injury in diverse animal models of diseases, including those that affect the kidney. These protective attributes are mainly due to: (i) prompt degradation of heme leading to restraining potential hazardous effects of free heme, and (ii) generation of byproducts that along with induction of ferritin have proven beneficial in a number of pathological conditions. This review will focus on describing clinical aspects of some of the conditions with the unifying end-result of increased heme burden and will discuss the molecular mechanisms that ensue to protect the kidneys.
MeSH
Kidney Diseases, Hemolysis, Rhabdomyolysis, Ferritins, Heme Oxygenase-1
Cited by
- Major heme proteins hemoglobin and myoglobin with respect to their roles in oxidative stress - a brief review. Front Chem, 2025
- Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy. Liver Int, 2024
- Heme Proteins and Kidney Injury: Beyond Rhabdomyolysis. Kidney360, 2022
- Counteraction of Myocardial Ferritin Heavy Chain Deficiency by Heme Oxygenase-1. Int J Mol Sci, 2022
- Navigating the Complex Pathogenesis of Acute Kidney Injury: Exploring Macrophage Dynamics, Mitochondrial Dysfunction, and Ferroptosis Pathways. Adv Kidney Dis Health, 2025
- Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species. Am J Physiol Renal Physiol, 2024
- Molecular Mechanisms of Iron and Heme Metabolism. Annu Rev Nutr, 2022