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Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Ppublish 4 citations

PubMed: 34375971 DOI: 10.1159/000517056

Urinary Kringle Domain-Containing Protein HGFL: A Validated Biomarker of Early Sickle Cell Anemia-Associated Kidney Disease.

Am J Nephrol 52(7):582-587

Authors: Sergei Nekhai, Xionghao Lin, Simran Soni, Ammanuel Taye, Nathan Smith, Nowah Afangbedji, Santosh L Saraf, Victor R Gordeuk, James G Taylor, Marina Jerebtsova

Affiliations

  • Department of Microbiology, College of Medicine, Howard University, Washington, District of Columbia, USA.
  • Center for Sickle Cell Disease, College of Medicine, Howard University, Washington, District of Columbia, USA.
  • Department of Medicine, College of Medicine, Howard University, Washington, District of Columbia, USA.
  • Department of Oral Pathology, College of Dentistry, Howard University, Washington, District of Columbia, USA.
  • Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

Abstract

INTRODUCTION

Chronic kidney disease (CKD) is a prevalent complication of sickle cell anemia (SCA). Hyperfiltration that delayed detection of CKD is common in SCA patients. Identification of novel urinary biomarkers correlating with glomerular filtration rates may help to detect and predict progression of renal disease.

METHODS

Reanalysis of mass spectra of urinary samples obtained from University of Illinois at Chicago identified kringle domain-containing protein HGFL.

RESULTS

HGFL levels correlated with hyperfiltration, were significantly reduced at CKD stage 1 compared to stage 0, negatively correlated with progression of CKD and were suitable for differentiation of stage 1. Better prediction of CKD progression to stage 2 was observed for HGFL-based risk prediction compared to the estimated glomerular filtration rate (eGFR)-based prediction. Results from a Howard University patient cohort supported the utility of HGFL-based test for the differentiation of stage 1 of CKD.

CONCLUSION

Urinary HGFL may contribute additional information beyond eGFR and improve diagnosis of early-stage CKD in SCA patients.

MeSH

Anemia, Sickle Cell, Glomerular Filtration Rate, Kidney Diseases, Biomarkers, Cells, Nephrology

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