Journal Article Ppublish 10 citations
PubMed: 34459194 DOI: 10.1021/acs.jafc.1c04123
Inhibitory Activities of Sulfur Compounds in Garlic Essential Oil against Alzheimer's Disease-Related Enzymes and Their Distribution in the Mouse Brain.
J Agric Food Chem 69(35):10163-10173
Authors: Yuri Yoshioka, Shinichi Matsumura, Masanori Morimoto, Yuki Takemoto, Chihiro Kishi, Tatsuya Moriyama, Nobuhiro Zaima
Affiliations
- INABATA KORYO, Co. Ltd. 3-5-20 Tagawa, Yodogawa, Osaka 532-0027, Japan.
- Department of Applied Biological Chemistry, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan.
- Agricultural Technology and Innovation Research Institute, Kindai University, Nara 631-8505, Japan.
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disease. Garlic reportedly has various physiological effects, including a role in protecting against dementia. However, the action mechanisms of garlic on AD are not entirely clear. In this study, we investigated the inhibitory activity of garlic essential oil (GEO) against AD-related enzymes and evaluated the distribution of active substances in GEO to the brain. We found that several sulfur compounds in GEO significantly inhibited AD-related enzymes. Sulfur compounds were detected in the serum and brain 6 h post administration. The ratios of allyl mercaptan (24.0 ± 3.9%) and allyl methyl sulfide (49.8 ± 15.6%) in the brain were significantly higher than those in GEO, while those of dimethyl trisulfide (0.89 ± 34.8%), allyl methyl trisulfide (0.41 ± 19.0%), and diallyl trisulfide (0.43 ± 72.8%) in the brain were significantly lower than those in GEO. Similar results were observed in the serum, suggesting that the organosulfur compounds were converted to allyl mercaptan or allyl methyl sulfide in the body. Although allyl mercaptan and allyl methyl sulfide are not the main components of GEO, they might be key molecules to understand the bioactivities of GEO in the body.
MeSH
Enzymes, Alzheimer Disease, Brain, Cholinesterases, Oils, Volatile, Chemistry, Agricultural, Sulfur Compounds, Serum, Food-Processing Industry
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