Journal Article Epublish 10 citations
PubMed: 34630163 DOI: 10.3389/fphys.2021.743399
Nocturnal Hypoxemia Rather Than Obstructive Sleep Apnea Is Associated With Decreased Red Blood Cell Deformability and Enhanced Hemolysis in Patients With Sickle Cell Disease.
Front Physiol 12:743399
Authors: Emeric Stauffer, Solène Poutrel, Giovanna Cannas, Alexandra Gauthier, Romain Fort, Yves Bertrand, Céline Renoux, Philippe Joly, Camille Boisson, Arnaud Hot, Laure Peter-Derex, Vincent Pialoux, Thierry PetitJean, Philippe Connes
Affiliations
- Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team ≪ Vascular Biology and Red Blood Cell ≫, University Claude Bernard Lyon 1, Lyon, France.
- Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France.
- Centre de Médecine du Sommeil et des Maladies Respiratoires, Hospices Civils de Lyon, Hôpital Croix Rousse, Lyon, France.
- Service d'Explorations Fonctionnelles Respiratoires-Médecine du sport et de l'activité physique, Hospices Civils de Lyon, Lyon, France.
- Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
- Institut d'Hématologique et d'Oncologique Pédiatrique, Hospices Civils de Lyon, Lyon, France.
- Service de Réanimation Médicale, Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France.
- Laboratoire de Biochimie et de Biologie Moléculaire, UF de Biochimie des Pathologies Erythrocytaires, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Lyon, France.
- Centre de recherche en Neurosciences de Lyon, CNRS UMR 5292, INSERM U 1028, Universite Claude Bernard Lyon 1, Lyon, France.
Abstract
Although obstructive sleep apnea (OSA) could act as a modulator of clinical severity in sickle cell disease (SCD), few studies focused on the associations between the two diseases. The aims of this study were: (1) to explore the associations between OSA, nocturnal oxyhemoglobin saturation (SpO2) and the history of several acute/chronic complications, (2) to investigate the impact of OSA and nocturnal SpO2 on several biomarkers (hematological, blood rheological, and coagulation) in patients with SCD. Forty-three homozygous SCD patients underwent a complete polysomnography recording followed by blood sampling. The proportion of patients suffering from nocturnal hypoxemia did not differ between those with and those without OSA. No association between OSA and clinical severity was found. Nocturnal hypoxemia was associated with a higher proportion of patients with hemolytic complications (glomerulopathy, leg ulcer, priapism, or pulmonary hypertension). In addition, nocturnal hypoxemia was accompanied by a decrease in RBC deformability, enhanced hemolysis and more severe anemia. Nocturnal hypoxemia in SCD patients could be responsible for changes in RBC deformability resulting in enhanced hemolysis leading to the development of complications such as leg ulcers, priapism, pulmonary hypertension or glomerulopathy. www.ClinicalTrials.gov, identifier: NCT03753854.
MeSH
Erythrocytes, Anemia, Sickle Cell, Sleep Apnea Syndromes, Blood Cells, Sleep Apnea, Obstructive, Hemolysis, Leg Ulcer, Hypertension, Pulmonary, Priapism