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Publications

Journal Article Systematic Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Ppublish 22 citations

PubMed: 34806918 DOI: 10.1177/0271678X211056702

Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques.

J Cereb Blood Flow Metab 42(5):700-717

Authors: Moss Y Zhao, Amanda Woodward, Audrey P Fan, Kevin T Chen, Yannan Yu, David Y Chen, Michael E Moseley, Greg Zaharchuk

Affiliations

  • Department of Radiology, Stanford University, Stanford, CA, USA.
  • Lane Medical Library, Stanford University, Stanford, CA, USA.
  • Department of Biomedical Engineering, University of California Davis, Davis, CA, USA.
  • Department of Neurology, University of California Davis, Davis, CA, USA.
  • Department of Medical Imaging, Taipei Medical University - Shuan-Ho Hospital, New Taipei City.
  • Department of Radiology, School of Medicine, Taipei Medical University, Taipei *Research materials supporting this publication can be accessed at https://doi.org/10.25740/hd852bg4538.

Abstract

Cerebrovascular reactivity (CVR), the capacity of the brain to increase cerebral blood flow (CBF) to meet changes in physiological demand, is an important biomarker to evaluate brain health. Typically, this brain "stress test" is performed by using a medical imaging modality to measure the CBF change between two states: at baseline and after vasodilation. However, since there are many imaging modalities and many ways to augment CBF, a wide range of CVR values have been reported. An understanding of CVR reproducibility is critical to determine the most reliable methods to measure CVR as a clinical biomarker. This review focuses on CVR reproducibility studies using neuroimaging techniques in 32 articles comprising 427 total subjects. The literature search was performed in PubMed, Embase, and Scopus. The review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We identified 5 factors of the experimental subjects (such as sex, blood characteristics, and smoking) and 9 factors of the measuring technique (such as the imaging modality, the type of the vasodilator, and the quantification method) that have strong effects on CVR reproducibility. Based on this review, we recommend several best practices to improve the reproducibility of CVR quantification in neuroimaging studies.

MeSH

Research Design, Brain, Cerebrovascular Circulation, Blood, Neuroimaging

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