Journal Article Review Epublish 25 citations
PubMed: 35054835 DOI: 10.3390/ijms23020649
Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing.
Int J Mol Sci 23(2)
Authors: Siarhei A Dabravolski, Vasily N Sukhorukov, Vladislav A Kalmykov, Nikolay A Orekhov, Andrey V Grechko, Alexander N Orekhov
Affiliations
- Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora Str. 210026 Vitebsk, Belarus.
- Laboratory of Cellular and Molecular Pathology of Cardiovascular System, AP Avtsyn Research Institute of Human Morphology, 3 Tsyurupy Str. 117418 Moscow, Russia.
- Laboratory of Medical Genetics, Russian Medical Research Center of Cardiology, Institute of Experimental Cardiology, 15-a 3-rd Cherepkovskaya Str. 121552 Moscow, Russia.
- Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia.
- Institute for Atherosclerosis Research, 4-1-207 Osennyaya Str. 121609 Moscow, Russia.
- Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 14-3 Solyanka Str. 109240 Moscow, Russia.
Abstract
Cardiovascular diseases (CVDs) are the leading cause of death globally, representing approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart protection against stresses and age-mediated accumulation of toxic misfolded proteins by regulation of the protein synthesis/degradation balance and refolding of misfolded proteins, thus supporting the high metabolic demand of the heart cells. Heat shock protein 90 (HSP90) is one of the main cardioprotective chaperones, represented by cytosolic and , mitochondrial and ER-localised isoforms. Currently, the main way to study the functional role of HSPs is the application of HSP inhibitors, which could have a different way of action. In this review, we discussed the recently investigated role of HSP90 proteins in cardioprotection, atherosclerosis, CVDs development and the involvements of HSP90 clients in the activation of different molecular pathways and signalling mechanisms, related to heart ageing.
MeSH
Heart, Cardiovascular Diseases, Therapeutics, Atherosclerosis, Heat-Shock Proteins
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