Journal Article Epublish 29 citations
PubMed: 35207138 DOI: 10.3390/membranes12020217
Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology.
Membranes (Basel) 12(2)
Authors: Claudia Trejo-Soto, Guillermo R Lázaro, Ignacio Pagonabarraga, Aurora Hernández-Machado
Affiliations
- Instituto de Física, Pontificia Universidad Católica de Valparaiso, Casilla 4059, Chile.
- Departament de Física de la Materia Condensada, Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain.
- CECAM, Centre Europeén de Calcul Atomique et Moleéculaire, École Polytechnique Feédeérale de Lausanne (EPFL), Batochime-Avenue Forel 2, 1015 Lausanne, Switzerland.
- Universitat de Barcelona Institute of Complex Systems (UBICS), Universitat de Barcelona, 08028 Barcelona, Spain.
- Centre de Recerca Matemàtica, Edifici C, Campus de Bellaterra, 08193 Barcelona, Spain.
- Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain.
Abstract
In this article, we describe the general features of red blood cell membranes and their effect on blood flow and blood rheology. We first present a basic description of membranes and move forward to red blood cell membranes' characteristics and modeling. We later review the specific properties of red blood cells, presenting recent numerical and experimental microfluidics studies that elucidate the effect of the elastic properties of the red blood cell membrane on blood flow and hemorheology. Finally, we describe specific hemorheological pathologies directly related to the mechanical properties of red blood cells and their effect on microcirculation, reviewing microfluidic applications for the diagnosis and treatment of these diseases.
MeSH
Hemodynamics, Erythrocytes, Cell Membrane, Membranes, Blood Cells, Hemorheology, Rheology, Microfluidics
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