Journal Article Meta-Analysis Systematic Review Research Support, N.I.H., Extramural Ppublish 7 citations
PubMed: 35209795 DOI: 10.1080/17474086.2022.2043743
Factors associated with blood pressure variation in sickle cell disease patients: a systematic review and meta-analyses.
Expert Rev Hematol 15(4):359-368
Authors: Arthemon Nguweneza, Chandré Oosterwyk, Kambe Banda, Victoria Nembaware, Gaston Mazandu, Andre P Kengne, Ambroise Wonkam
Affiliations
- Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
- Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.
Abstract
OBJECTIVES
Blood pressure (BP) values ≥120/70 mmHg considerably increase the risk of pulmonary hypertension and renal dysfunction in Sickle Cell Disease (CSD) patients and ultimately increased morbidity and mortality. This has led to the development of the term relative systemic hypertension (RSH). RSH was defined as Systolic BP 120-139 mm Hg or diastolic BP 70-89 mm Hg, whereas systemic hypertension is defined as Systolic BP ≥ 140 mm Hg or diastolic BP ≥ 90 mm Hg. Systematic identification of BP variations and risk factors in SCD patients could promote effective management. This review aimed to identify factors associated with BP variation among SCD patients.
METHODS
We searched PubMed, Scopus, Web of Science, and Google Scholar up to December 2020 with no geographical or language restrictions. Two reviewers independently screened and summarized data from eligible studies.
RESULTS
Advancing age, gender, higher body weight, hemoglobin, eGFR, triglycerides, greater hematocrit, higher blood viscosity, history of blood transfusion, and targeted variants in DRD2 and MIR4301 genes were independently associated with the risk of hypertension in SCD patients.
CONCLUSION
Interventions that consider these risk factors may potentially contribute to lower BP pressure in SCD patients and prevent the development of severe complications.
MeSH
Hematologic Diseases, Anemia, Sickle Cell, Hypertension, Risk Factors, Cells, Blood Pressure
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