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Journal Article Epublish 6 citations

PubMed: 35222083 DOI: 10.3389/fphys.2022.814979

Brain Oxygen Extraction and Metabolism in Pediatric Patients With Sickle Cell Disease: Comparison of Four Calibration Models.

Front Physiol 13:814979

Authors: Zixuan Lin, Tiffany McIntyre, Dengrong Jiang, Alicia Cannon, Peiying Liu, Aylin Tekes, James F Casella, Keith Slifer, Hanzhang Lu, Eboni Lance

Affiliations

  • The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
  • Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, United States.
  • Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, United States.
  • Division of Pediatric Hematology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
  • Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, MD, United States.
  • Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
  • F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States.
  • Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Abstract

Sickle cell disease (SCD) is an inherited hemoglobinopathy with an increased risk of neurological complications. Due to anemia and other factors related to the underlying hemoglobinopathy, cerebral blood flow (CBF) increases as compensation; however, the nature of alterations in oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO) in SCD remains controversial, largely attributed to the different calibration models. In addition, limited studies have been done to investigate oxygen metabolism in pediatric patients. Thus, this study used a non-invasive T-based MR oximetry, T-Relaxation-Under-Spin-Tagging (TRUST) MRI, to measure oxygen homeostasis in pediatric patients with SCD using four different calibration models and examined its relationship to hematological measures. It was found that, compared with controls, SCD patients showed an increased CBF, unchanged total oxygen delivery and increased venous blood T. The results of OEF and CMRO were dependent on the calibration models used. When using sickle-specific, hemoglobin S (HbS) level-dependent calibration, there was a decreased OEF and CMRO, while the bovine model showed an opposite result. OEF and CMRO were also associated with hemoglobin and HbS level; the direction of the relationship was again dependent on the model. Future studies with calibration are needed to provide more accurate information on the T-Y relationship.

MeSH

Hemoglobinopathies, Anemia, Sickle Cell, Brain, Cells, Blood, Hemoglobins

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