Journal Article Ppublish 3 citations
PubMed: 35282153 DOI: 10.3390/math9243323
A Mathematical Model for early HBV and -HDV Kinetics during Anti-HDV Treatment.
Mathematics (Basel) 9(24)
Authors: Rami Zakh, Alexander Churkin, William Bietsch, Menachem Lachiany, Scott J Cotler, Alexander Ploss, Harel Dahari, Danny Barash
Affiliations
- Department of Computer Science, Ben-Gurion University, Beer-Sheva 8410501, Israel.
- Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 8410501, Israel.
- Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
- Jerusalem College of Technology, Jerusalem 91160, Israel.
- Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Abstract
Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.
MeSH
Infections, Therapeutics, Hepatitis Delta Virus
Cited by
- Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients. Mathematics (Basel), 2022