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Publications

Journal Article Research Support, Non-U.S. Gov't Epublish 10 citations

PubMed: 35336861 DOI: 10.3390/v14030455

Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in Healthcare Workers and COVID-19 Patients.

Viruses 14(3)

Authors: Luzia Maria de-Oliveira-Pinto, Victor Edgar Fiestas Solórzano, Maria de Lourdes Martins, Caroline Fernandes-Santos, Paula Hesselberg Damasco, Marilda Agudo Mendonça Teixeira de Siqueira, Helver Gonçalves Dias, Alex Pauvolid-Corrêa, Paulo Vieira Damasco, Elzinandes Leal de Azeredo

Affiliations

  • Viral Immunology Laboratory, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro 21040-360, Brazil.
  • Rede Casa Hospital Rio Laranjeiras e Rio Botafogo, Rio de Janeiro 22240-000, Brazil.
  • Departamento de Clínica Médica, Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro 242010-240, Brazil.
  • Laboratório de Vírus Respiratório e Sarampo, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro 21040-360, Brazil.
  • Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA.
  • Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-170, Brazil.
  • Faculdade de Medicina, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

Abstract

Advances in knowledge of the pathophysiology of COVID-19 have been acquired; however, the host factors that could explain the mild and severe forms of the disease are not fully understood. Thus, we proposed to evaluate anti-SARS-CoV-2 antibodies and the inflammatory response of different groups of individuals, including healthcare workers (HCW), sick and dead COVID-19 patients and also recovered patients to contribute to this knowledge gap. Our objective is to relate the clinical evolution of these individuals with the level of detection and functionality of specific antibodies and with the production of inflammatory mediators. As main findings, IgA and IgG anti-SARS-CoV-2 were detected in asymptomatic HCW. IFN-γ and TNF-α levels were higher in symptomatic HCWs than patients with COVID-19 and those who died. Patients who died had higher levels of IL-6, IL-10, and CCL2/MCP-1. We found an imbalance between antiviral and pro-inflammatory mediators in the groups, in which IFN-γ and TNF-α seem to be more associated with protection and IL-6 and CCL2/MCP-1 with pathology. Our work is pioneering the Brazilian population and corroborates data from people from other countries.

MeSH

Work, Antibodies, Health Personnel, Virology, Sars Virus, Covid-19, Sars-Cov-2

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