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Journal Article Research Support, Non-U.S. Gov't Epublish 20 citations

PubMed: 35372107 DOI: 10.3389/fcimb.2022.831186

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder.

Front Cell Infect Microbiol 12:831186

Authors: Shunjie Bai, Huili Bai, Detao Li, Qi Zhong, Jing Xie, Jian-Jun Chen

Affiliations

  • Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Institute of Life Sciences, Chongqing Medical University, Chongqing, China.
  • Chongqing Emergency Medical Center, Department of Endocrinology, The Fourth People's Hospital of Chongqing, Central Hospital of Chongqing University, Chongqing, China.

Abstract

Objective

Although many works have been done, the objectively measured diagnostic biomarkers are not available. Thus, we conducted this study to identify potential biomarkers for objectively diagnosing depression and explore the role of gut microbiota in the onset of depression.

Methods

Major depressive disorder (MDD) patients (n=56) and demographic data-matched healthy controls (HCs) (n=56) were included in this study. The gut microbiota in fecal samples and inflammation-related factors in serum were measured. Both univariate and multivariate statistical analyses were performed to identify the differential gut microbiota and inflammation-related factors.

Results

Finally, 46 differential operational taxonomic units (OTUs) (60.9% OTUs belonging to Firmicutes) and ten differential inflammation-related factors were identified. Correlation analysis showed that there were significant correlations between 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and seven differential inflammation-related factors. Meanwhile, 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and five differential inflammation-related factors (adiponectin, apolipoprotein A1, alpha 1-antitrypsin, neutrophilicgranulocyte count/white blood cell count and basophil count) were significantly correlated to depression severity. A panel consisting of these five differential inflammation-related factors could effectively diagnose MDD patients from HCs.

Conclusions

Our results suggested that Firmicutes, especially family Lachnospiraceae, might play a role in the onset of depression affecting the inflammation levels of host, and these five differential inflammation-related factors could be potential biomarkers for objectively diagnosing MDD.

MeSH

Depression, Biomarkers, Depressive Disorder, Cell Biology, Gastrointestinal Microbiome, Microbiota, Depressive Disorder, Major

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