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Publications

Journal Article Epublish 10 citations

PubMed: 35565475 DOI: 10.3390/cancers14092345

Surgical Implications of Advanced Low-Grade Serous Ovarian Cancer: Analysis of the Database of the Tumeurs Malignes Rares Gynécologiques Network.

Cancers (Basel) 14(9)

Authors: Hélène Bonsang-Kitzis, Nabilah Panchbhaya, Anne-Sophie Bats, Eric Pujade-Lauraine, Patricia Pautier, Charlotte Ngô, Marie-Aude Le Frère-Belda, Elsa Kalbacher, Anne Floquet, Dominique Berton-Rigaud, Claudia Lefeuvre-Plesse, Michel Fabbro, Isabelle Ray-Coquard, Fabrice Lécuru

Affiliations

  • Gynecological and Breast Surgery and Cancerology Center, RAMSAY-Générale de Santé, Hôpital Privé des Peupliers, 75013 Paris, France.
  • GINECO/TMRG Network, 75008 Paris, France.
  • Department of Obsterics and Gynecology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 75020 Paris, France.
  • Department of Breast and Gynecological Surgical Oncology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.
  • School of Medicine, Université de Paris, 75005 Paris, France.
  • Women Cancer Center and Clinical Research, Hôpital Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, 75006 Paris, France.
  • Department of Medical Oncology, Institut Gustave Roussy, 94000 Villejuif, France.
  • Department of Pathology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.
  • Department of Medical Oncology, Hôpital Jean Minjoz, 25000 Besançon, France.
  • Department of Medical Oncology, Institut Bergonié, 33000 Bordeaux, France.
  • Department of Medical Oncology, Institut de Cancérologie de l'Ouest-René Gauducheau, 44000 Saint Herblain, France.
  • Department of Medical Oncology, Centre Eugène Marquis, 35000 Rennes, France.
  • GINECO/TMRG Network, 75008 Paris, France. Department of Medical Oncology, Institut Régional du Cancer de Montpellier, 33000 Montpellier, France.
  • Department of Medical Oncology, Centre Léon Bérard, 69000 Lyon, France.
  • School of Medicine, Claude Bernard University, 69000 Lyon, France.
  • Department of Breast, Gynecology and Reconstructive Surgery, Institut Curie, 75005 Paris, France.

Abstract

The surgical specificities of advanced low-grade serous ovarian carcinoma (LGSOC) have been little investigated. Our objective was to describe surgical procedures/complications in primary (PDS) compared to interval debulking surgery (neoadjuvant chemotherapy and interval debulking surgery, NACT-IDS) and to assess the survival (progression-free (PFS) and overall survival (OS)) in patients with advanced LGSOC. We retrospectively analyzed advanced LGSOC from a nationwide registry (January 2000 to July 2017). A total of 127 patients were included (48% PDS and 35% NACT-IDS). Peritoneal carcinomatosis was more severe ( = 0.01 to 0.0001, according to sites), surgery more complex ( = 0.03) and late postoperative morbidity more frequent ( = 0.03) and more severe in the NACT-IDS group. PFS and OS were similar in patients with CC0 and CC1 residual disease after PDS or IDS. Prognosis was poorest for NACT-IDS patients with CC2/CC3 resection (PFS: HR = 2.31, IC95% (1.3-4.58); = 0.005; OS: HR = 4.98, IC95% (1.59-15.61); = 0.006). NACT has no benefit in terms of surgical outputs in patients with advanced LGSOC. Patients with complete resection or minimal residual disease (CC0 and CC1) have similar prognoses. On the other hand, patients with CC2 and more residual disease have similar survival rates compared to nonoperated patients. Primary cytoreduction with complete or with minimal residuals should be preferred when feasible.

MeSH

Ovary, Neoplasms, Ovarian Neoplasms, Prognosis

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