Journal Article Ppublish 10 citations
PubMed: 35675933 DOI: 10.15537/smj.2022.43.6.20220156
Serum neutrophil gelatinase-associated lipocalin concentrations are significantly associated with the severity of COVID-19 in pregnant patients.
Saudi Med J 43(6):559-566
Authors: Esra Can, Süleyman Cemil Oğlak, Fatma Ölmez, Huri Bulut
Affiliations
- From the Department of Obstetrics and Gynecology (Can, Ölmez), Health Sciences University, Kanuni Sultan Süleyman Training and Research Hospital, from the Department of Medical Biochemistry (Bulut), School of Medicine, Istinye University, Istanbul, and from the Department of Obstetrics and Gynecology (Oğlak), Health Sciences University, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.
Abstract
OBJECTIVES
To evaluate serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations of pregnant women complicated with coronavirus disease 2019 (COVID-19) and investigate its diagnostic value for the severity of COVID-19.
METHODS
Of the 46 pregnant women with COVID-19 included in the study, we further classified these women into 2 subgroups: the non-severe COVID-19 group (n=25) and the severe COVID-19 group (n=21).
RESULTS
Neutrophil gelatinase-associated lipocalin plasma concentrations were significantly higher in pregnant women complicated with severe COVID-19 (90 [53.1-207.7] ng/ml) compared to those from pregnant women with non-severe COVID-19 (51.8 [39.6-70.3] ng/ml) and healthy pregnant women (44.3 [32.2-54.1] ng/ml, <0.001). Also, at a cutoff value of 72 ng/ml, NGAL predicted severe COVID-19 with a sensitivity rate of 57% and a specificity rate of 84%. Serum NGAL level (adjusted hazard ratio [aHR]=1.020, 95% confidence interval [CI]= [1.006-1.035], =0.007), and D-dimer level (aHR=2.371, 95% CI= [1.085-5.181], =0.030) were the variables that were revealed to be significantly associated with the disease severity.
CONCLUSION
We demonstrated that NGAL was highly associated with COVID-19 severity. We consider that NGAL might be a useful biomarker to diagnose the disease severity in patients with COVID-19.
MeSH
Pregnant Women, Serum, Gelatinases, Lipocalin-2, Neutrophils, Covid-19, Lipocalins
Cited by
- The Relationship Between Kidney Biomarkers, Inflammation, Severity, and Mortality Due to COVID-19-A Two-Timepoint Study. Int J Mol Sci, 2025
- The course of infection with the Delta variant of COVID-19 in pregnancy: analysis of clinical, laboratory, and neonatal outcomes J Turk Ger Gynecol Assoc, 2022