Case Reports Ppublish 3 citations
PubMed: 35779576 DOI: 10.1016/j.clinbiochem.2022.06.011
Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease.
Clin Biochem 108:10-13
Authors: Guillaume Feugray, Camille Fontaine, Hélène Lanic, Jennifer Guillerme, Muriel Quillard Muraine
Affiliations
- Department of General Biochemistry, F-76000 Rouen, France, Normandie Univ, UNIROUEN, INSERMU1096 EnVI.
- Department of Biopathology, Centre Henri Becquerel, Rouen, France.
- Department of Clinical Hematology, Centre Henri Becquerel, Rouen, France.
- Department of General Biochemistry, Rouen University Hospital, Rouen, France.
- Department of General Biochemistry, Rouen University Hospital, F-76000 Rouen, and CIC-CRB, INSERM U1404, F-76000 Rouen and Normandie UNIV, UNIROUEN, INSERMU1073ADEN.
Abstract
Immunoassays are widely used in clinical laboratories because of their ease of use and low cost. These tests are based on antigen-antibody binding. However, clinicians and laboratory personnel may be confronted with immunoassay interference leading to difficulties in medical care. Here, we report a huge analytical discrepancy with IgG concentration higher than proteinemia in a 75-year-old man. Serum electrophoresis and immunofixation diagnosed γ-heavy chain disease. After investigation by different methods, the assay discrepancy was still present. We hypothesize that the interference is related to the truncated immunoglobulin secreted by the lymphoproliferative disorder.
MeSH
Laboratories, Serum, Biochemistry, Immunoglobulins, Immunoassay, Heavy Chain Disease