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Publications

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Epublish 11 citations

PubMed: 35805108 DOI: 10.3390/cells11132025

Integrin Regulators in Neutrophils.

Cells 11(13)

Authors: Sunitha Pulikkot, Liang Hu, Yunfeng Chen, Hao Sun, Zhichao Fan

Affiliations

  • Department of Immunology, School of Medicine, UConn Health, 263 Farmington Ave. Farmington, CT 06030, USA.
  • Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai 201203, China.
  • Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Blvd. Galveston, TX 77555, USA. Department of Pathology, University of Texas Medical Branch, 301 University Blvd. Galveston, TX 77555, USA.
  • Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Abstract

Neutrophils are the most abundant leukocytes in humans and are critical for innate immunity and inflammation. Integrins are critical for neutrophil functions, especially for their recruitment to sites of inflammation or infections. Integrin conformational changes during activation have been heavily investigated but are still not fully understood. Many regulators, such as talin, Rap1-interacting adaptor molecule (RIAM), Rap1, and kindlin, are critical for integrin activation and might be potential targets for integrin-regulating drugs in treating inflammatory diseases. In this review, we outline integrin activation regulators in neutrophils with a focus on the above critical regulators, as well as newly discovered modulators that are involved in integrin activation.

MeSH

Integrins, Cells, Neutrophils, Talin

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