Journal Article Ppublish
PubMed: 35831247 DOI: 10.1111/ped.15231
Utility of perinatal natriuretic peptide for predicting neonatal heart failure.
Pediatr Int 64(1):e15231
Authors: Takekazu Miyoshi, Hiroshi Hosoda, Akira Miyake, Heima Sakaguchi, Masataka Kitano, Ken-Ichi Kurosaki, Isao Shiraishi, Michikazu Nakai, Kunihiro Nishimura, Mikiya Miyazato, Kenji Kangawa, Jun Yoshimatsu, Naoto Minamino
Affiliations
- Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Suita, Japan.
- Clinical Research Center, National Center for Child Health and Development, Tokyo, Japan.
- Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan.
- Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center, Suita, Japan.
- Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Japan.
- Department of Biochemistry, National Cerebral and Cardiovascular Center, Suita, Japan.
- Department of Obstetrics and Gynecology, National Cerebral and Cardiovascular Center, Suita, Japan.
- Omics Research Center, National Cerebral and Cardiovascular Center, Suita, Japan.
Abstract
BACKGROUND
We evaluated the significance of perinatal plasma natriuretic peptide (NP) levels in neonates with congenital heart defects (CHDs) or arrhythmias and determined whether measurement of perinatal plasma NP levels and echocardiographic assessment in utero could predict heart failure after birth.
METHODS
The study was conducted between 2012 and 2016 to evaluate the correlation of perinatal atrial NP (ANP) and brain NP (BNP) levels at birth with the modified Ross score after birth and the cardiovascular profile (CVP) score before birth.
RESULTS
A total of 122 singletons with CHDs or arrhythmias and 27 controls were analyzed. Neonatal blood sampling was performed at a median of 0.7 h (range, 0.1-1.5) after birth. The neonatal plasma ANP and BNP levels shortly after birth were significantly higher than those in the umbilical artery (UA) plasma. The ANP and BNP levels in UA and neonatal blood were correlated with the modified Ross score. The neonatal plasma ANP and BNP levels and the modified Ross scores were inversely correlated with the CVP score in neonates with CHDs or arrhythmias. The area under the receiver operating characteristic curve of UA ANP levels for predicting neonatal heart failure was highest among those for the CVP score, perinatal plasma ANP and BNP levels, and their combinations.
CONCLUSIONS
The plasma ANP and BNP levels increased markedly shortly after birth. Assessment of the UA plasma ANP level at birth and the CVP score in utero may be utilized to predict neonatal heart failure.
MeSH
Heart Failure, Plasma, Pediatrics, Arrhythmias, Cardiac, Heart Defects, Congenital, Parturition, Blood, Infant, Newborn, Natriuretic Peptides