System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Epublish 12 citations

PubMed: 35844759 DOI: 10.3389/fped.2022.883185

Cord Blood SARS-CoV-2 IgG Antibodies and Their Association With Maternal Immunity and Neonatal Outcomes.

Front Pediatr 10:883185

Authors: Addy Cecilia Helguera-Repetto, Isabel Villegas-Mota, Guadalupe Itzel Arredondo-Pulido, Jorge Arturo Cardona-Pérez, Moises León-Juárez, Maria Antonieta Rivera-Rueda, Gabriela Arreola-Ramírez, Paloma Mateu-Rogell, Sandra Acevedo-Gallegos, Gloria Elena López-Navarrete, María Yolotzin Valdespino-Vázquez, Guadalupe Martínez-Salazar, Mario Rodríguez-Bosch, Irma Alejandra Coronado-Zarco, María Del Rosario Castillo-Gutiérrez, Carlos Alberto Cuevas-Jiménez, Elsa Romelia Moreno-Verduzco, Salvador Espino-Y-Sosa, Manuel Cortés-Bonilla, Claudine Irles

Affiliations

  • Department of Immunobiochemistry, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Department of Infectious Diseases and Epidemiology, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • General Director, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Neonatal Intensive Care Unit, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Department of Pediatric Follow-Up, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Clinical Research Subdivision, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Department of Materno-Fetal Medicine, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Department of Pathological Anatomy, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Gynecology and Obstetrics Subdivision, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Neonatalogy Subdivision, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Laboratorio Lapi S.A. de C.V. Mexico City, Mexico.
  • Diagnostic Auxiliary Services, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Medical Division, Instituto Nacional de Perinatología, Mexico City, Mexico.
  • Department of Physiology and Cellular Development, Instituto Nacional de Perinatología, Mexico City, Mexico.

Abstract

Passive transplacental immunity is crucial for neonatal protection from infections. Data on the correlation between neonatal immunity to SARS-CoV-2 and protection from adverse outcomes is scarce. This work aimed to describe neonatal seropositivity in the context of maternal SARS-CoV-2 infection, seropositivity, and neonatal outcomes. This retrospective nested case-control study enrolled high-risk pregnant women with a SARS-CoV-2 RT-PCR positive test who gave birth at the Instituto Nacional de Perinatología in Mexico City and their term neonates. Anti-SARS-CoV-2 IgG antibodies in maternal and cord blood samples were detected using a chemiluminescent assay. In total, 63 mother-neonate dyads (mean gestational age 38.4 weeks) were included. Transplacental transfer of SARS-CoV-2 IgG occurred in 76% of neonates from seropositive mothers. A positive association between maternal IgG levels and Cycle threshold (Ct) values of RT-qPCR test for SARS-CoV-2 with neonatal IgG levels was observed. Regarding neonatal outcomes, most seropositive neonates did not require any mechanical ventilation, and none developed any respiratory morbidity (either in the COVID-19 positive or negative groups) compared to 7 seronegative neonates. Furthermore, the odds of neonatal respiratory morbidity exhibited a tendency to decrease when neonatal IgG levels increase. These results add further evidence suggesting passive IgG transfer importance.

MeSH

Pregnancy, Sars-Cov-2, Mothers, Blood, Infant, Newborn, Antibodies, Covid-19, Immunity, Morbidity, Severe Acute Respiratory Syndrome-Related Coronavirus, Infections

Cited by