Journal Article Epublish 21 citations
PubMed: 35887634 DOI: 10.3390/jpm12071137
Association between Peripheral Inflammatory Cytokines and Cognitive Function in Patients with First-Episode Schizophrenia.
J Pers Med 12(7)
Authors: Seon-Hwa Baek, Honey Kim, Ju-Wan Kim, Seunghyong Ryu, Ju-Yeon Lee, Jae-Min Kim, Il-Seon Shin, Sung-Wan Kim
Affiliations
- Department of Psychiatry, Chonnam National University Medical School, Gwangju 61419, Korea.
- Department of Psychiatry, Chonnam National University Medical School, Gwangju 61419, Korea. Mindlink, Gwangju Bukgu Mental Health Center, Gwangju 61220, Korea.
Abstract
In this study, we investigated the impact of inflammatory cytokines on the cognitive performance of patients with schizophrenia. The included patients met the criteria for schizophrenia spectrum disorder and were aged between 15 and 40 years, with a duration of illness ≤1 year. Plasma tumor necrosis factor (TNF)-α; interferon-γ; and interleukin (IL)-1β, IL-6, IL-8, IL-10, and IL-12 levels were measured. A computerized neurocognitive battery, measures for social cognitive function, and clinical measures were administered. A total of 174 patients with first-episode psychosis were enrolled. The TNF-α level was negatively correlated with scores on the digit span, verbal learning, and Wisconsin card sorting tests, and the number of correct responses on the continuous performance test (CR-CPT), whereas a positive correlation was detected with the trail making test (TMT)-B time. The interferon-γ level was negatively correlated with performance on the false belief and visual learning tests. The IL-1β level was positively correlated with the TMT-A time and CPT reaction time, whereas it was negatively correlated with the CR-CPT and performance on the visual learning and social cognitive tests. The IL-12 level was negatively correlated with the CR-CPT and false belief test. Our results suggest that proinflammatory cytokines are associated with cognitive impairment in patients with schizophrenia.
MeSH
Cytokines, Cognitive Dysfunction, Schizophrenia, Cognition Disorders, Learning, Psychotic Disorders, Cognition
Cited by
- Variations in inflammatory regulators in male patients with chronic schizophrenia associated with psychopathology and cognitive deficits. BMC Psychiatry, 2024
- Association between suicidal ideation and cognitive function in young patients with schizophrenia spectrum disorder. Front Psychiatry, 2023
- Peripheral inflammation and neurocognitive functioning in early psychosis: Specific associations of TNF-α and IL-6 with social cognition. Eur Psychiatry, 2025
- Inflammatory markers and cognitive deficits in first-episode psychoses - A cross-sectional study. Indian J Psychiatry, 2025
- Relationships Between Immune-Inflammatory Features and Social Cognitive Impairments in Patients With Schizophrenia Spectrum Disorders: A Systematic Review. Brain Behav, 2025