Journal Article Review Epublish 33 citations
PubMed: 36014122 DOI: 10.3390/mi13081200
Engineering Organ-on-a-Chip to Accelerate Translational Research.
Micromachines (Basel) 13(8)
Authors: Jihoon Ko, Dohyun Park, Somin Lee, Burcu Gumuscu, Noo Li Jeon
Affiliations
- Department of Mechanical Engineering, Seoul National University, Seoul 08826, Korea.
- Bio-MAX Institute, Seoul National University, Seoul 08826, Korea.
- Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Korea.
- Biosensors and Devices Laboratory, Biomedical Engineering Department, Institute for Complex Molecular Systems, Eindhoven Artificial Intelligence Systems Institute, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
- Department of Mechanical Engineering, Seoul National University, Seoul 08826, Korea. Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Korea. Institute of Advanced Machines and Design, Seoul National University, Seoul 08826, Korea.
Abstract
We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments. The organ-on-chip platform consists of microfluidic channels, cell culture chambers, and stimulus sources that emulate the in-vivo microenvironment. These platforms are typically engraved into an oxygen-permeable transparent material. Fabrication of these materials requires the use of microfabrication strategies, including soft lithography, 3D printing, and injection molding. Here we provide an overview of what is an organ-on-chip platform, where it can be used, what it is composed of, how it can be fabricated, and how it can be operated. In connection with this topic, we also introduce an overview of the recent applications, where different organs are modeled on the microscale using this technology.
MeSH
Cells, Microtechnology, Technology, Tissues, Cell Culture Techniques, Translational Research, Biomedical
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