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Publications

Journal Article Research Support, N.I.H., Extramural Epublish 15 citations

PubMed: 36068212 DOI: 10.1038/s41467-022-33002-8

Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics.

Nat Commun 13(1):5247

Authors: Yide Zhang, Binglin Shen, Tong Wu, Jerry Zhao, Joseph C Jing, Peng Wang, Kanomi Sasaki-Capela, William G Dunphy, David Garrett, Konstantin Maslov, Weiwei Wang, Lihong V Wang

Affiliations

  • Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
  • Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. Key Laboratory of Space Photoelectric Detection and Perception, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China.
  • Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

Abstract

Many ultrafast phenomena in biology and physics are fundamental to our scientific understanding but have not yet been visualized owing to the extreme speed and sensitivity requirements in imaging modalities. Two examples are the propagation of passive current flows through myelinated axons and electromagnetic pulses through dielectrics, which are both key to information processing in living organisms and electronic devices. Here, we demonstrate differentially enhanced compressed ultrafast photography (Diff-CUP) to directly visualize propagations of passive current flows at approximately 100 m/s along internodes, i.e., continuous myelinated axons between nodes of Ranvier, from Xenopus laevis sciatic nerves and of electromagnetic pulses at approximately 5 × 10 m/s through lithium niobate. The spatiotemporal dynamics of both propagation processes are consistent with the results from computational models, demonstrating that Diff-CUP can span these two extreme timescales while maintaining high phase sensitivity. With its ultrahigh speed (picosecond resolution), high sensitivity, and noninvasiveness, Diff-CUP provides a powerful tool for investigating ultrafast biological and physical phenomena.

MeSH

Biological Science Disciplines, Axons, Pulse

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