Journal Article Review Research Support, N.I.H., Extramural Ppublish 12 citations
PubMed: 36122544 DOI: 10.1016/j.coi.2022.102245
Immunometabolic alterations in lupus: where do they come from and where do we go from there?
Curr Opin Immunol 78:102245
Authors: Longhuan Ma, Tracoyia Roach, Laurence Morel
Affiliations
- Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health San Antonio, 7703 Floyd Curl Dr. MC7758, San Antonio, TX, 78229-3900, USA.
- Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health San Antonio, 7703 Floyd Curl Dr. MC7758, San Antonio, TX, 78229-3900, USA.
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease in which the overactivation of the immune system has been associated with metabolic alterations. Targeting the altered immunometabolism has been proposed to treat SLE patients based on their results obtained and mouse models of the disease. Here, we review the recent literature to discuss the possible origins of the alterations in the metabolism of immune cells in lupus, the dominant role of mitochondrial defects, technological advances that may move the field forward, as well as how targeting lupus immunometabolism may have therapeutic potential.
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