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Journal Article Review Ppublish 9 citations

PubMed: 36168329 DOI: 10.1016/j.apsb.2022.09.011

Localized delivery of nanomedicine and antibodies for combating COVID-19.

Acta Pharm Sin B 13(5):1828-1846

Authors: Bin Tu, Yanrong Gao, Xinran An, Huiyuan Wang, Yongzhuo Huang

Affiliations

  • State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. University of Chinese Academy of Sciences, Beijing 100049, China.
  • State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • University of Michigan College of Pharmacy, Ann Arbor, MI 48109, USA.
  • State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. University of Chinese Academy of Sciences, Beijing 100049, China. Zhongshan Institute for Drug Discovery, SIMM, CAS, Zhongshan 528437, China. NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Shanghai 201203, China. Taizhou University, School of Advanced Study, Institute of Natural Medicine and Health Product, Taizhou 318000, China.

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been a major health burden in the world. So far, many strategies have been investigated to control the spread of COVID-19, including social distancing, disinfection protocols, vaccines, and antiviral treatments. Despite the significant achievement, due to the constantly emerging new variants, COVID-19 is still a great challenge to the global healthcare system. It is an urgent demand for the development of new therapeutics and technologies for containing the wild spread of SARS-CoV-2. Inhaled administration is useful for the treatment of lung and respiratory diseases, and enables the drugs to reach the site of action directly with benefits of decreased dose, improved safety, and enhanced patient compliance. Nanotechnology has been extensively applied in the prevention and treatment of COVID-19. In this review, the inhaled nanomedicines and antibodies, as well as intranasal nanodrugs, for the prevention and treatment of COVID-19 are summarized.

MeSH

Sars-Cov-2, Nanomedicine, Antibodies, Pharmaceutical Preparations, Covid-19, Therapeutics

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