Journal Article Epublish 1 citation
PubMed: 36230315 DOI: 10.3390/ani12192576
Marine-Sulfated Polysaccharides Extracts Exhibit Contrasted Time-Dependent Immunomodulatory and Antiviral Properties on Porcine Monocytes and Alveolar Macrophages.
Animals (Basel) 12(19)
Authors: Caroline Hervet, Frédérick Bussy, Claude Le Goff, Déborah Ménard, Pi Nyvall Collén, Matthieu Le Goff, François Meurens, Nicolas Bertho
Affiliations
- BIOEPAR, INRAE, Oniris, 44300 Nantes, France.
- OLMIX SA, 56580 Bréhan, France.
- Department of Veterinary Microbiology and Immunology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.
Abstract
Porcine respiratory complex syndrome has a strong economic impact on the swine breeding sector, as well as a clear repercussion on the wellbeing of the animals, leading to overuse of antimicrobial molecules. Algal extracts used in short-term treatments are empirically recognized by farmers as having a positive effect on pigs' health, however, their mechanisms of action are not well known and more research is needed. Herein we studied the short and median term impact of three algal extracts, in vitro, on the pro-inflammatory and antiviral responses of porcine primary blood monocytes and alveolar macrophages, as well as the susceptibility of the treated cells to infection by Porcine Respiratory and Reproductive Syndrome Virus (PRRSV) and the Aujeszky's Disease Virus (ADV). All extracts presented a pro-inflammatory short-term effect, associated for two of them, with an inhibition of the PRRSV replication. Conversely, the three extracts presented an anti-inflammatory median term effect, with no impact on PRRSV replication. The observed immune modulation prompts us to test, in vivo, the anti-PRRSV action of algal extracts and strengthen the interest for this natural resource.
MeSH
Polysaccharides, Infections, Antiviral Agents, Porcine Respiratory And Reproductive Syndrome Virus, Viruses, Monocytes, Macrophages, Alveolar