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Journal Article Review Research Support, Non-U.S. Gov't Epublish 28 citations

PubMed: 36291105 DOI: 10.3390/cells11203237

Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions.

Cells 11(20)

Authors: Han Guo, Elhusseny A Bossila, Xinran Ma, Chenxu Zhao, Yong Zhao

Affiliations

  • State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. University of Chinese Academy of Sciences, Beijing 101499, China.
  • State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
  • University of Chinese Academy of Sciences, Beijing 101499, China.
  • Biotechnology Department, Faculty of Agriculture Al-Azhar University, Cairo 11311, Egypt.
  • Beijing Institute for Stem Cell and Regeneration, Beijing 100101, China.

Abstract

Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine, plays critical roles in maintaining host homeostasis and in pathological conditions, such as allergy, infectious diseases, and cancer, by acting on multiple types of immune cells and promoting type 1 and 2 immune responses. IL-33 is rapidly released by immune and non-immune cells upon stimulation by stress, acting as an "alarmin" by binding to its receptor, suppression of tumorigenicity 2 (ST2), to trigger downstream signaling pathways and activate inflammatory and immune responses. It has been recognized that IL-33 displays dual-functioning immune regulatory effects in many diseases and has both pro- and anti-tumorigenic effects, likely depending on its primary target cells, IL-33/sST2 expression levels, cellular context, and the cytokine microenvironment. Herein, we summarize our current understanding of the biological functions of IL-33 and its roles in the pathogenesis of various conditions, including inflammatory and autoimmune diseases, infections, cancers, and cases of organ transplantation. We emphasize the nature of context-dependent dual immune regulatory functions of IL-33 in many cells and diseases and review systemic studies to understand the distinct roles of IL-33 in different cells, which is essential to the development of more effective diagnoses and therapeutic approaches for IL-33-related diseases.

MeSH

Cytokines, Cells, Neoplasms, Alarmins, Immune System, Immunity, Interleukin-33, Organ Transplantation

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