Journal Article Review Epublish 20 citations
PubMed: 36296012 DOI: 10.3390/mi13101659
Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review.
Micromachines (Basel) 13(10)
Authors: Di Jiang, Shaowei Liu, Wenlai Tang
Affiliations
- College of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China. Jiangsu Yuyue Medical Equipment and Supply Co. Ltd. Danyang 212300, China.
- College of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China.
- School of Electrical and Automation Engineering, Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing 210023, China.
Abstract
Non-spherical shape is a general appearance feature for bioparticles. Therefore, a mechanical mechanism study of non-spherical particle migration in a microfluidic chip is essential for more precise isolation of target particles. With the manipulation of non-spherical particles, refined disease detection or medical intervention for human beings will be achievable in the future. In this review, fabrication and manipulation of non-spherical particles are discussed. Firstly, various fabrication methods for non-spherical microparticle are introduced. Then, the active and passive manipulation techniques for non-spherical particles are briefly reviewed, including straight inertial microchannels, secondary flow inertial microchannels and deterministic lateral displacement microchannels with extremely high resolution. Finally, applications of viscoelastic flow are presented which obviously increase the precision of non-spherical particle separation. Although various techniques have been employed to improve the performance of non-spherical particle manipulation, the universal mechanism behind this has not been fully discussed. The aim of this review is to provide a reference for non-spherical particle manipulation study researchers in every detail and inspire thoughts for non-spherical particle focused device design.
MeSH
Microfluidics
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