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Publications

Journal Article Epublish 7 citations

PubMed: 36358201 DOI: 10.3390/antibiotics11111545

Effects of Vitamin D on the Renin-Angiotensin System and Acute Childhood Pneumonia.

Antibiotics (Basel) 11(11)

Authors: Andrea Zovi, Francesco Ferrara, Roberta Pasquinucci, Livia Nava, Antonio Vitiello, Roberto Arrigoni, Andrea Ballini, Stefania Cantore, Raffele Palmirotta, Marina Di Domenico, Luigi Santacroce, Mariarosaria Boccellino

Affiliations

  • Ministry of Health, Viale Giorgio Ribotta 5, 00144 Rome, Italy.
  • Pharmaceutical Department, Asl Napoli 3 Sud, Dell'amicizia Street 22, Nola, 80035 Naples, Italy.
  • Pharmaceutical Department, Asl Napoli 2 Nord, Frattamaggiore, 80027 Naples, Italy.
  • CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), 70124 Bari, Italy.
  • Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
  • Independent Researcher, Regional Dental Community Service "Sorriso&Benessere-Ricerca e Clinica", 70129 Bari, Italy.
  • Interdisciplinary Department of Medicine, School of Medicine, University of Bari "Aldo Moro", 70129 Bari, Italy.

Abstract

Vitamin D promotes kidney calcium reabsorption and regulates calcium and phosphate metabolism, as well as the intestinal absorption of calcium and phosphorus and bone mineralization events. Vitamin D is also known for its immunomodulatory properties. It has been shown in the literature that the active form of vitamin D, 1,25-dihydroxyvitamin D, performs multiple functions in the adaptive and innate immune system, as well as acting on the endothelial membrane. Recent evidence shows that vitamin D is a negative endocrine modulator of the renin-angiotensin system (RAS), with protection from diseases leading to lung damage, such as pneumonia caused by various pathogens. Vitamin D support associated with the use of antibiotics could be crucial to counteract these infectious diseases.

MeSH

Renin-Angiotensin System, Pharmacology, Vitamins, Communicable Diseases, Pneumonia, Angiotensins, Calcium, Absorption, Vitamin D

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