Journal Article Research Support, N.I.H., Extramural Ppublish 8 citations
PubMed: 36382420 DOI: 10.1111/bjh.18548
Characterising the prevalence of overweight and obese status among adults with sickle cell disease.
Br J Haematol 200(5):633-642
Authors: Stephanie O Ibemere, Charity I Oyedeji, Liliana Preiss, Laura E Van Althuis, Jane S Hankins, Melissa Azul, Ebony N Burns, Jeffrey Glassberg, Ward Hagar, Faiz Hussain, Allison King, Cathy Melvin, John Myers, Angela Snyder, Nirmish Shah, Paula Tanabe
Affiliations
- Duke University School of Nursing, Durham, North Carolina, USA.
- Department of Medicine, Division of Hematology, Duke University School of Medicine, Durham, North Carolina, USA.
- RTI International, Durham, North Carolina, USA.
- Duke Office of Clinical Research, Durham, North Carolina, USA.
- St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
- Mount Sinai, New York, New York, USA.
- University of California San Francisco, San Francisco, California, USA.
- University of Illinois at Chicago, Chicago, Illinois, USA.
- Washington University in St. Louis, St. Louis, Missouri, USA.
- Medical University of South Carolina, Charleston, South Carolina, USA.
- Georgia State University, Atlanta, Georgia, USA.
- Duke University Hospital, Durham, North Carolina, USA.
- Duke University School of Nursing and Medicine, Durham, North Carolina, USA.
Abstract
Individuals with sickle cell disease (SCD) have historically been considered underweight. Despite increasing body mass index (BMI) in the general population, the prevalence of overweight and obese status remains unclear in the adult SCD population. Our primary aim was to determine the prevalence of overweight and obese status and to identify associations between BMI, demographic, and clinical characteristics. We conducted an analysis of abstracted electronic health record data and patient-reported outcomes from the Sickle Cell Disease Implementation Consortium registry; individuals aged 20-45 years were included. The median (interquartile range) BMI for the 1664 adults in this analysis was 23.9 (21.1-28) kg/m . In this cohort, 42.9% had a BMI of >25 kg/m (Centers for Disease Control and Prevention definition of overweight/obese). In multivariable analysis, higher odds of being overweight or obese were associated with female gender, older age, college education, private insurance, and hypertension diagnosis. Higher odds of a BMI of >25 kg/m were observed in individuals with HbSC or HbSβ thalassaemia regardless of hydroxycarbamide (hydroxyurea) exposure (odds ratio [OR] 3.4, p < 0.0001) and HbSS or HbSβ thalassaemia exposed to hydroxycarbamide (OR 1.6, p = 0.0003) compared to those with HbSS or HbSβ thalassaemia with no hydroxycarbamide exposure. These data highlight the importance of early identification, prevention, and intervention for increasing BMI to reduce obesity-related complications that may impact SCD-related complications.
MeSH
Cells, Body Mass Index, Anemia, Sickle Cell, Centers For Disease Control And Prevention, U.S., Prevalence, Obesity, Overweight