Journal Article Review Ppublish 14 citations
PubMed: 36400540 DOI: 10.1016/j.hoc.2022.07.014
The Cardiopulmonary Complications of Sickle Cell Disease.
Hematol Oncol Clin North Am 36(6):1217-1237
Authors: Ankit A Desai, Roberto F Machado, Robyn T Cohen
Affiliations
- Department of Medicine, Indiana School of Medicine, Indianapolis, IN, USA; Indiana University, 950 W. Walnut Street R2 Building, Room 466, Indianapolis, IN 46202, USA.
- Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Room C400, Walther Hall, R3 980 W. Walnut Street, Indianapolis, IN 46202, USA.
- Department of Pediatrics, Boston Medical Center/Boston University School of Medicine, 801 Albany Street 4th Floor, Boston, MA 02118, USA.
Abstract
Sickle cell disease (SCD) is a genetic hemoglobinopathy associated with extensive morbidity and early mortality. While there have been recent improvements in available disease-modifying therapies for SCD, cardiopulmonary complications remain a major risk factor for death in this population. We provide an overview of current knowledge regarding several of the major acute and chronic cardiopulmonary complications in SCD, including: acute chest syndrome, airway disease, lung function abnormalities, nocturnal hypoxemia and sleep disordered breathing, pulmonary vascular disease, and sickle cell cardiomyopathy.
MeSH
Cells, Hematology, Anemia, Sickle Cell, Medical Oncology
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- The role of the pulmonary function laboratory in the management of hematologic diseases. J Bras Pneumol, 2024
- Mouse models of sickle cell disease: Imperfect and yet very informative. Blood Cells Mol Dis, 2023