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Publications

Journal Article Review Ppublish 4 citations

PubMed: 36415483 DOI: 10.1186/s42269-022-00955-1

The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis.

Bull Natl Res Cent 46(1):267

Authors: Antoine AbdelMassih, Hala Agha, Sonia El-Saiedi, Amal El-Sisi, Meryam El Shershaby, Hanya Gaber, Habiba-Allah Ismail, Nadine El-Husseiny, Abeer Reda Amin, Aly ElBoraie, Aya Ayad, Esraa Menshawey, Fady Sefein, Ibrahim Ihab Osman, Mai Moursi, Maram Hanafy, Mariam Sherif Abdelaziz, Mariem Badr Arsanyous, Mariam Khaled-Ibn-El-Walid, Marwa Gamal Tawfik, Menna Habib, Mina Ehab Mansour, Mirette Ashraf, Mohamed Ayman Khattab, Nada Alshehry, Nada Hafez, Naheel Essam ElDeeb, Nirvana Ashraf, Noha Khalil, Noheir Ismail AbdElSalam, Noura Shebl, Nouran Gamal Ali Hafez, Nourhan Hatem Youssef, Odette Bahnan, Passant Ismail, Peter Kelada, Rahma Menshawey, Rana Saeed, Reem Jalal Husseiny, Reem Yasser, Safa Sharaf, Veronia Adel, Youstina Naeem, Youstina Nagy Farid Nicola, Aya Kamel, Rafeef Hozaien, Raghda Fouda

Affiliations

  • Pediatric Cardiology Unit, Pediatrics' Department, Faculty of Medicine, Cairo University, P.O. Box 12411, Cairo, Egypt.
  • Pediatric Cardio-Oncology Clinic, Children Cancer Hospital of Egypt, Cairo, Egypt.
  • Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Faculty of Dentistry, Cairo University, Cairo, Egypt.
  • Pixagon Graphic Design Agency, Cairo, Egypt.
  • Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Abstract

Background

Several reports of unheeded complications secondary to the current mass international rollout of SARS-COV-2 vaccines, one of which is myocarditis occurring with the FDA fully approved vaccine, Pfizer, and others.

Main body of the abstract

Certain miRNAs (non-coding RNA sequences) are involved in the pathogenesis in viral myocarditis, and those miRNAs are interestingly upregulated in severe COVID-19. We hypothesize that the use of mRNA-based vaccines may be triggering the release of host miRNAs or that trigger the occurrence of myocarditis. This is based on the finding of altered host miRNA expression promoting virus-induced myocarditis.

Short conclusion

In conclusion, miRNAs are likely implicated in myocarditis associated with mRNA vaccines. Our hypothesis suggests the use of miRNA as a biomarker for the diagnosis of mRNA vaccine-induced myocarditis. Additionally, the interplay between viral miRNA and the host immune system could alter inflammatory profiles, hence suggesting the use of therapeutic inhibition to prevent such complications.

MeSH

Myocarditis, Micrornas, Rna, Messenger, Rna, Untranslated, Covid-19 Vaccines

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