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Journal Article Review Epublish 35 citations

PubMed: 36430794 DOI: 10.3390/ijms232214317

Renal Fibrosis in Lupus Nephritis.

Int J Mol Sci 23(22)

Authors: Savino Sciascia, Martina Cozzi, Alice Barinotti, Massimo Radin, Irene Cecchi, Roberta Fenoglio, Daniele Mancardi, Georgia Wilson Jones, Daniela Rossi, Dario Roccatello

Affiliations

  • University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit, Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley (North-West Italy), Department of Clinical and Biological Sciences, San Giovanni Bosco Hub Hospital, University of Turin, 10154 Turin, Italy.

Abstract

Fibrosis can be defined as a pathological process in which deposition of connective tissue replaces normal parenchyma. The kidney, like any organ or tissue, can be impacted by this maladaptive reaction, resulting in persistent inflammation or long-lasting injury. While glomerular injury has traditionally been regarded as the primary focus for classification and prognosis of lupus nephritis (LN), increasing attention has been placed on interstitial fibrosis and tubular atrophy as markers of injury severity, predictors of therapeutic response, and prognostic factors of renal outcome in recent years. This review will discuss the fibrogenesis in LN and known mechanisms of renal fibrosis. The importance of the chronicity index, which was recently added to the histological categorization of LN, and its role in predicting treatment response and renal prognosis for patients with LN, will be explored. A better understanding of cellular and molecular pathways involved in fibrosis in LN could enable the identification of individuals at higher risk of progression to chronic kidney disease and end-stage renal disease, and the development of new therapeutic strategies for lupus patients.

MeSH

Kidney Failure, Chronic, Lupus Erythematosus, Systemic, Lupus Nephritis, Prognosis, Therapeutics, Fibrosis, Tissues

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