Journal Article Research Support, Non-U.S. Gov't Ppublish 5 citations
PubMed: 36453182 DOI: 10.4155/fmc-2022-0187
Synthesis and antimalarial activity of 7-chloroquinoline-tethered sulfonamides and their [1,2,3]-triazole hybrids.
Future Med Chem 14(23):1725-1739
Authors: Neha Batra, Drishti Agarwal, Ishan Wadi, Chandra Sekhar Tekuri, Rinkoo D Gupta, Mahendra Nath
Affiliations
- Department of Chemistry, Faculty of Science, University of Delhi, Delhi, 110 007, India.
- Faculty of Life Sciences & Biotechnology, South Asian University, New Delhi, India.
Abstract
Drugs with multiple bioactive moieties have the advantages of multiple modes of action and fewer chances of drug resistance. In continuation of our previous work of developing hybrid antimalarials, we present herein the synthesis and antimalarial activity of two different series of 7-chloroquinoline-sulfonamide hybrids. The first series of compounds were synthesized by using -dodecylbenzenesulfonic acid as a Bronsted acid catalyst in ethanol. The second series' compounds were synthesized by 1,3-dipolar cycloaddition of azides and alkynes under click reaction conditions. The majority of these compounds demonstrated noncytotoxicity and significant antimalarial activity against (3D7) with IC values in the range of 1.49-13.49 μM. The most promising hybrids (, and may be good starting points for next-generation antimalarials.
MeSH
Pharmaceutical Preparations, Antimalarials, Chemistry, Pharmaceutical, Triazoles, Sulfonamides