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Journal Article Review Epublish 9 citations

PubMed: 36467604 DOI: 10.3389/fncel.2022.1005399

Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment.

Front Cell Neurosci 16:1005399

Authors: Riyun Yang, Jingying Pan, Yankai Wang, Panhui Xia, Mingliang Tai, Zhihao Jiang, Gang Chen

Affiliations

  • Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
  • Center for Basic Medical Research, Medical School of Nantong University, Nantong, China.
  • Center for Basic Medical Research, Medical School of Nantong University, Nantong, China. Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China. Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, China.

Abstract

Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes, oligodendrocytes, microglia and other non-neuronal cells become dysfunctional, hindering the repair of the injured spinal cord. Corrective surgery and biological, physical and pharmacological therapies are commonly used treatment modalities for SCI; however, no current therapeutic strategies can achieve complete recovery. Somatic cell reprogramming is a promising technology that has gradually become a feasible therapeutic approach for repairing the injured spinal cord. This revolutionary technology can reprogram fibroblasts, astrocytes, NG2 cells and neural progenitor cells into neurons or oligodendrocytes for spinal cord repair. In this review, we provide an overview of the transcription factors, genes, microRNAs (miRNAs), small molecules and combinations of these factors that can mediate somatic cell reprogramming to repair the injured spinal cord. Although many challenges and questions related to this technique remain, we believe that the beneficial effect of somatic cell reprogramming provides new ideas for achieving functional recovery after SCI and a direction for the development of treatments for SCI.

MeSH

Cells, Oligodendroglia, Astrocytes, Spinal Cord, Neurons, Micrornas, Spinal Cord Injuries, Recycling, Cellular Reprogramming, Fibroblasts, Therapeutics, Spine

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