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Publications

Journal Article Review Epublish 17 citations

PubMed: 36558533 DOI: 10.3390/nu14245374

Protective Role of Natural Compounds under Radiation-Induced Injury.

Nutrients 14(24)

Authors: Annamaria Altomare, Michele Fiore, Gabriele D'Ercole, Elena Imperia, Roberta Maria Nicolosi, Susanna Della Posta, Gabriella Pasqua, Michele Cicala, Laura De Gara, Sara Ramella, Michele Pier Luca Guarino

Affiliations

  • Unit of Food Science and Nutrition, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
  • Research Unit of Gastroenterology, Università Campus Biomedico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
  • NBFC, National Biodiversity Future Center, 90133 Palermo, Italy.
  • Operative Research Unit of Radiation Oncology, Fondazione Policlinico Universitario Campus Biomedico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
  • Research Unit of Radiation Oncology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Rome, Italy.
  • Department of Environmental Biology, Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
  • Operative Research Unit of Gastroenterology, Fondazione Policlinico Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Rome, Italy.

Abstract

In recent years, evidence has shown the potential therapeutic effects of different natural compounds for the prevention and treatment of radiotherapy-induced mucositis (RIOM). RIOM represents one of the most frequent side effects associated with anti-neoplastic treatments affecting patients' quality of life and treatment response due to radiation therapy discontinuation. The innate radio-protective ability of natural products obtained from plants is in part due to the numerous antioxidants possessed as a part of their normal secondary metabolic processes. However, oxygen presence is a key point for radiation efficacy on cancer cells. The aim of this review is to describe the most recent evidence on radiation-induced injury and the emerging protective role of natural compounds in preventing and treating this specific damage without compromising treatment efficacy.

MeSH

Radiotherapy, Mucositis, Food, Therapeutics

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