Journal Article Ppublish 13 citations
PubMed: 36567142 DOI: 10.1016/j.vaccine.2022.12.043
Association of dual COVID-19 and seasonal influenza vaccination with COVID-19 infection and disease severity.
Vaccine 41(4):875-878
Authors: Zhigang Xie, Hanadi Y Hamadi, Arch G Mainous, Young-Rock Hong
Affiliations
- Department of Public Health, University of North Florida, Jacksonville, FL, United States.
- Department of Health Administration, University of North Florida, Jacksonville, FL, United States.
- Department of Health Services Research, Management, and Policy, University of Florida, Gainesville, FL, United States; Department of Community Health and Family Medicine, University of Florida, Gainesville, FL, United States.
- Department of Health Services Research, Management, and Policy, University of Florida, Gainesville, FL, United States.
Abstract
The clinical guideline states that COVID-19 vaccination can be administered concurrently with Influenza (flu) vaccination (dual vaccination). Using data from the 2021 National Health Interview Survey, we conducted descriptive analysis and multivariate logistic regressions to examine the association between dual vaccination status and self-reported COVID-19 infection and severity. Among 21,387 (weighted 185,251,310) U.S. adults, about 22% did not receive either the flu or COVID-19 vaccine, 6.0% received the flu vaccine only, 29.1% received the COVID-19 vaccine only, and 42.5% received both vaccines. In the multivariate analysis, individuals with dual vaccination (OR, 0.65, 95% CI, 0.56-0.75) and COVID-19 vaccine only (OR, 0.71, 95% CI, 0.61-0.82) were significantly less likely to report COVID-19 infection when compared with those unvaccinated. There was no significant difference in self-reported COVID-19 symptom severity by vaccination status. The results suggest that dual vaccination may be an effective strategy to reduce the contagious respiratory disease burden.
MeSH
Vaccines, Vaccination, Covid-19, Influenza, Human, Infections
Cited by
- Clinical characteristics of COVID-19 in children and adolescents: insights from an Italian paediatric cohort using a machine-learning approach. BMJ Public Health, 2025
- Concurrent administration of COVID-19 vaccine and seasonal influenza vaccine: No increased estimated vaccine-related mortality rate. Indian J Pharmacol, 2023
- Combining COVID-19 and seasonal influenza vaccines together to increase the acceptance of newly developed vaccines in the Eastern Mediterranean Region: a cross-sectional study. Ann Med, 2023
- Progress in combination vaccines and the co-administration of influenza virus and SARS-CoV-2 vaccines. Front Immunol, 2025
- Influenza immunization of healthcare personnel in the post-COVID-19 pandemic era: Still a lot to do! Vaccine X, 2023